ArticleVeterinary research2017
Efficacy of a polyvalent immersion vaccine against Flavobacterium psychrophilum and evaluation of immune response to vaccination in rainbow trout fry (Onchorynchus mykiss L.).
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Effects of Increased Water Salinity and Temperature on the Development of Rainbow Trout Fry Syndrome (RTFS) Caused by Flavobacterium psychrophilum.Journal of fish diseases · 2026Article
- Transcriptional investigation of immune gene expression dynamics in Rohu (Labeo rohita) in response to killed Flavobacterium columnare vaccine.Molecular biology reports · 2025Article
- Methylation of foreign DNA overcomes the restriction barrier ofApplied and environmental microbiology · 2025Article
- AI-Driven Realtime Monitoring of Early Indicators for Ichthyophthirius multifiliis Infection of Rainbow Trout.Journal of fish diseases · 2025Article
- Genome-wide association analysis of resistance to bacterial cold-water disease in an important rainbow trout aquaculture breeding population.Frontiers in genetics · 2025Article
- Quality of DNA extracted from freshwater fish scales and mucus and its application in genetic diversity studies ofBiology methods & protocols · 2023Article
- Plasma proteomic profiling of bacterial cold water disease-resistant and -susceptible rainbow trout lines and biomarker discovery.Frontiers in immunology · 2023Article
- Article
- Factors Affecting Post-Challenge Survival ofPathogens (Basel, Switzerland) · 2022Article
- Immersion challenge model for Flavobacterium psychrophilum infection of Atlantic salmon (Salmo salar L.) fry.Journal of fish diseases · 2022Article
- Effect of an Oral Bivalent Vaccine on Immune Response and Immune Gene Profiling in Vaccinated Red Tilapia (Biology · 2022Article
- Skin mucus proteins of rainbow trout (Oncorhynchus mykiss) in response to mucosal vaccination and challenge with Flavobacterium psychrophilum.Journal of fish diseases · 2022Article
- Detecting Flavobacterial Fish Pathogens in the Environment via High-Throughput Community Analysis.Applied and environmental microbiology · 2022Article
- A BCWD-Resistant line of rainbow trout is less sensitive to cortisol implant-induced changes in IgM response as compared to a susceptible (control) line.Developmental and comparative immunology · 2021Article
- Aquaculture Reuse Water, Genetic Line, and Vaccination Affect Rainbow Trout (Frontiers in immunology · 2021Article
- Review
- Vaccination Route Determines the Kinetics and Magnitude of Nasal Innate Immune Responses in Rainbow Trout (Biology · 2020Article
- Quantification of Defensive Proteins in Skin Mucus ofAnimals : an open access journal from MDPI · 2020Article
- Targeted Delivery of Mannosylated Nanoparticles Improve Prophylactic Efficacy of Immersion Vaccine against Fish Viral Disease.Vaccines · 2020Article
- Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism.Journal of nanobiotechnology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rainbow trout fry syndrome (RTFS) is a disease caused by the Gram-negative bacterium Flavobacterium psychrophilum, responsible for significant economic losses in salmonid aquaculture worldwide. The diversity of F. psychrophilum isolates and the inherent difficulties in vaccinating juvenile fish has hampered the development of a vaccine for RTFS. Disease episodes tend to occur between 10-14 °C with necrotic lesions often seen on the skin surrounding the dorsal fin and tail. At present no commercial vaccines are available for RTFS in the UK, leaving antibiotics as the only course of action to control disease outbreaks. The current work was performed as a pilot study to assess the efficacy of a polyvalent, whole cell vaccine containing formalin-inactivated F. psychrophilum, to induce protective immunity in rainbow trout fry. Duplicate groups of 30 trout (5 g) were immersed in 1 L of the vaccine for 30 s. Samples were taken 4 h, day 2 and 7 post-vaccination (pv) of skin mucus, tissues for histology and gene expression analysis; serum and histology samples were taken 6 weeks pv. A booster vaccination was given at 315 degree days (dd) also by immersion. Challenge was by immersion with a heterologous isolate of F. psychrophilum 630 dd post primary vaccination. The vaccine provided significant protection to the trout fry with a RPS of 84% (p < 0.0001). Detection of increased numbers of IgT positive cells in systemic organs, up-regulation of IgT expression in hind-gut and an increase in total IgT in serum was observed in vaccinated fish; however a functional role of IgT in the observed protection remains to be demonstrated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.