ArticleEnvironmental health : a global access science source2017
Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Renal transcriptome-wide analyses in association with kidney black carbon load.Particle and fibre toxicology · 2025Article
- Exposure to fine particulate matter in adults is associated with immune cell gene expression related to inflammation, the electron transport chain, and cell cycle regulation.Environmental epigenetics · 2025Article
- Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells.PloS one · 2024Article
- Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.JCI insight · 2023Article
- Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.Current environmental health reports · 2022Review
- Article
- The lag effect of exposure to PMEnvironmental science and pollution research international · 2022Article
- Prematurity alters the progenitor cell program of the upper respiratory tract of neonates.Scientific reports · 2021Article
- Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells.Stem cells international · 2021Article
- Comparative analysis of lung and blood transcriptomes in mice exposed to multi-walled carbon nanotubes.Toxicology and applied pharmacology · 2020Article
- The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats.Frontiers in medicine · 2020Article
- Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response.Biology · 2019Review
- Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.Mitochondrion · 2019Article
- Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.American journal of respiratory and critical care medicine · 2018Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to their lack of repair capacity mitochondria are critical targets for environmental toxicants. We studied genes and pathways reflecting mitochondrial responses to short- and medium-term PM
methodsWhole genome gene expression was measured in peripheral blood of 98 adults (49% women). We performed linear regression analyses stratified by sex and adjusted for individual and temporal characteristics to investigate alterations in gene expression induced by short-term (week before blood sampling) and medium-term (month before blood sampling) PM
resultsOverrepresentation analyses revealed significant pathways (p-value <0.05) related to mitochondrial genome maintenance and apoptosis for short-term exposure and to the electron transport chain (ETC) for medium-term exposure in women. For men, medium-term PM
conclusionsIn this exploratory study, we identified mitochondrial genes and pathways associated with particulate air pollution indicating upregulation of energy producing pathways as a potential mechanism to compensate for PM-induced mitochondrial damage.
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