Evidence map›Paper›PMID 28821285›Full record

ArticleEnvironmental health : a global access science source2017

Genetic and epigenetic susceptibility of airway inflammation to PM

Yue Zhang, Muhammad T Salam, Kiros Berhane, Sandrah P Eckel, Edward B Rappaport, William S Linn, Rima Habre, Theresa M Bastain, Frank D Gilliland

Open access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Short-term effect of PMScientific reports · 2026
    Article
  3. Review
  4. Long-term PMERJ open research · 2025
    Article
  5. Long-term PMPediatric research · 2025
    Article
  6. Airway inflammation, asthma, and soot.Pediatric research · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yue ZhangDivision of Epidemiology, Department of Internal Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84018, USA. zhang.yue@hsc.utah.edu.ORCID 0000-0002-4124-4816
Muhammad T SalamDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Kiros BerhaneDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Sandrah P EckelDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Edward B RappaportDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
William S LinnDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Rima HabreDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Theresa M BastainDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Frank D GillilandDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity of Utah · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AVOL, EDWARD · 2002 to 2011
$30.2M
Urban Air Pollution &Persistent Early Life AsthmaP01ES009581 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 1999 to 2010
$6.8M
FACTORS IN CHILDHOOD LUNG SUSCEPTIBILITY TO POLLUTIONR01HL061768 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 1999 to 2008
$4.4M
Air Pollution, Inflammation and New Onset AsthmaR01HL076647 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 2005 to 2009
$3.6M
Early detection of adverse respiratory effects from air pollutionR01ES023262 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERHANE, KIROS T, GILLILAND, FRANK D. · 2013 to 2016
$2.0M
Methods for modeling air pollution effects on exhaled biomarkersK22ES022987 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ECKEL, SANDRAH PROCTOR · 2013 to 2015
$478k
NHLBI NIH HHS R01 HL061768NHLBI NIH HHS R01 HL076647NIEHS NIH HHS K22 ES022987NIEHS NIH HHS P01 ES009581NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES023262
6 · The paper itself

Abstract

backgroundThe fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that has proved to be useful in investigations of genetic and epigenetic airway susceptibility to ambient air pollutants. For example, susceptibility to airway inflammation from exposure to particulate matter with aerodynamic diameter < =2.5 μm (PM

methodsThe study included 940 school children in the southern California Children's Health Study who provided concurrent buccal samples and FeNO measurements. We used quantile regression to examine susceptibility by estimating the quantile-specific joint effects of PM

resultsWe discovered striking differences in susceptibility to PM

conclusionSchool-aged children with higher FeNO have greater genetic and epigenetic susceptibility to PM

Indexed as

Environmental ExposureEpigenesis, GeneticAir PollutantsAsthmaCaliforniaChildExhalationFemaleGenetic Predisposition to DiseaseHumansInflammationMaleNitric OxideNitric Oxide Synthase Type IIParticulate MatterRegression AnalysisAir PollutantsNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanParticulate MatterAsthmaExhaled nitric oxideHaplotypeInducible nitric oxide synthaseMethylationPM2.5

Identifiers

PMID28821285
PMCPMC5563051
OpenAlexW2745710000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.