Evidence map›Paper›PMID 28821284›Full record

Trial reportBMC cancer2017

Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) study: design of a randomized controlled trial.

Jonna K van Vulpen, Peter D Siersema, Richard van Hillegersberg, Grard A P Nieuwenhuijzen, Ewout A Kouwenhoven, Richard P R Groenendijk, Donald L van der Peet, Eric J Hazebroek, Camiel Rosman, Carlo C G Schippers and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138223 (The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06138223 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)

TypeinterventionalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2024 to 2028Enrolled196ConditionsGastroEsophageal Cancer, Incurable DiseaseArmsExercise intervention, Nutrition intervention
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Perceived facilitators and barriers by esophageal cancer survivors participating in a post-treatment exercise program.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Health-related quality of life after esophagectomy in patients with esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2022
    Review
  11. Article
  12. Article
  13. Variability and limitations in home-based exercise program descriptions in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  14. Article
  15. Review
  16. Recent advancements in esophageal cancer treatment in Japan.Annals of gastroenterological surgery · 2018
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Jonna K van VulpenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands.
Peter D SiersemaDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands.
Richard van HillegersbergDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands.
Grard A P NieuwenhuijzenDepartment of Surgery, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.
Ewout A KouwenhovenDepartment of Surgery, ZGT Hospital, Zilvermeeuw 1, 7609 PP, Almelo, The Netherlands.
Richard P R GroenendijkDepartment of Surgery, IJsselland Hospital, Prins Constantijnweg 2, 2906 ZC, Capelle a/d IJssel, The Netherlands.
Donald L van der PeetDepartment of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Eric J HazebroekDepartment of Surgery, St. Antonius Hospital, Koekoekslaan 1, 3430 VB, Nieuwegein, The Netherlands.
Camiel RosmanDepartment of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Carlo C G SchippersDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands.
Elles SteenhagenDepartment of Dietetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands.
Petra H M PeetersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. A.M.May@umcutrecht.nl.
University Medical Center Utrecht · NLHeidelberg University · DERadboud University Nijmegen · NLAmsterdam UMC Location VUmc · NLIJsselland Ziekenhuis · NLSt. Antonius Ziekenhuis · NLZiekenhuis Groep Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFollowing esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of esophageal cancer survivors, the burden of disease- and treatment-related complaints and symptoms becomes more relevant. This emphasizes the need for interventions aimed at improving quality of life. Beneficial effects of post-operative physical exercise have been reported in several cancer types, but so far comparable evidence in esophageal cancer patients is lacking. The aim of this study is to investigate effects of physical exercise on health-related quality of life in esophageal cancer patients following surgery.

methodsThe Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) study is a multicenter randomized controlled trial including 150 esophageal cancer patients after surgery with curative intent. Patients are randomly allocated to an exercise group or usual care group. The exercise group participates in a 12-week combined aerobic and resistance exercise program, supervised by a physiotherapist near the patient's home-address. In addition, participants in the exercise group are requested to be physically active for at least 30 min per day, every day of the week. Participants allocated to the usual care group are asked to maintain their habitual physical activity pattern. The primary outcome is health-related quality of life (EORTC-QLQ-C30). Secondary outcomes include esophageal cancer specific quality of life, fatigue, anxiety and depression, sleep quality, work-related factors, cardiorespiratory fitness (VO DISCUSSION: This randomized controlled trial investigates effects of physical exercise versus usual care in esophageal cancer patients after surgery. As the design of the exercise program closely resembles daily practice, this study can contribute both to evidence on effects of exercise in esophageal cancer patients, and to potential implementation strategies.

trial registrationTrial registration:Netherlands Trial Registry NTR5045 Date of trial registration: January 19th, 2015 Date and version study protocol: February 2017, version 1.

Indexed as

Clinical ProtocolsExerciseExercise TherapyPostoperative CareEsophageal NeoplasmsHumansQuality of LifeResearch DesignResistance TrainingTreatment OutcomeEsophageal cancerPhysical exerciseQuality of lifeRandomized controlled trial

Identifiers

PMID28821284
PMCPMC5562993
OpenAlexW2746975988

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.