ArticleBMC infectious diseases2017
Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Tuberculosis infection tests for contact screening in Brazil: a cost-effectiveness analysis.Lancet regional health. Americas · 2026Article
- Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Infectious and clinical tuberculosis trajectories: Bayesian modeling with case finding implications.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Responding to the post-pandemic crisis: post-exposure prophylaxis for TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Article
- Latent tuberculosis infection in family members in household contact with active tuberculosis patients in Semarang City, Central Java, Indonesia.Journal of public health in Africa · 2022Article
- The absence of evidence of cure is not a risk for recurrent TB among patients treated for TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021Article
- Immunological basis of early clearance of Mycobacterium tuberculosis infection: the role of natural killer cells.Clinical and experimental immunology · 2021Review
- Severe undernutrition in children affects tuberculin skin test performance in Southern India.PloS one · 2021Article
- Hot and Cold Spot Areas of Household Tuberculosis Transmission in Southern China: Effects of Socio-Economic Status andInternational journal of environmental research and public health · 2019Article
- Multiple exposures, reinfection and risk of progression to active tuberculosis.Royal Society open science · 2019Article
- Review
- Early clearance versus control: what is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure toF1000Research · 2018Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundIn household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversion. It remains unclear whether this delay in M. tuberculosis infection is related to differences in the infectious exposure, TST boosting, partial host resistance, or some other factor.
methodsWe conducted a household contact study Vitória, Brazil. Between 2008 and 2013, we identified culture-positive pulmonary TB patients and evaluated their household contacts with both a TST and interferon gamma release assay (IGRA), and identified TST converters at 8-12 weeks post study enrollment. Contacts were classified as TST-positive (≥10 mm) at baseline, TST converters, or persistently TST-negative. We compared TST converters to TST-positive and to TST-negative contacts separately, using generalized estimating equations.
resultsWe enrolled 160 index patients and 838 contacts; 523 (62.4%) were TST+, 62 (7.4%) TST converters, and 253 (30.2%) TST-. TST converters were frequently IGRA- at 8-12 weeks. In adjusted analyses, characteristics distinguishing TST converters from TST+ contacts (no contact with another TB patient and residence ownership) were different than those differentiating them from TST- contacts (stronger cough in index patient and contact BCG scar).
conclusionsThe individual risk and timing of M. tuberculosis infection within households is variable and dependent on index patient, contact and environmental factors within the household, and the surrounding community. Our findings suggest a threshold effect in the risk of infection in humans.
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