ArticleBMC genomics2017
Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Primary transcript enrichment reveals a density-dependentFrontiers in microbiology · 2026Article
- Transcriptomic characterization ofMicrobiome research reports · 2025Article
- Controlling arbovirus infection: high-throughput transcriptome and proteome insights.Frontiers in microbiology · 2024Review
- Article
- Impact of CHIKV Replication on the Global Proteome ofProteomes · 2022Article
- The effect of the endosymbiont Wolbachia on the behavior of insect hosts.Insect science · 2020Review
- Quantitative Proteomic Analysis of Chikungunya Virus-InfectedJournal of proteome research · 2020Article
- Complete Genome Sequence of the Wolbachia wAlbB Endosymbiont of Aedes albopictus.Genome biology and evolution · 2019Article
- Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation.PLoS pathogens · 2018Article
- Article
- Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV.Journal of autoimmunity · 2018Review
- Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques.Frontiers in cellular and infection microbiology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAedes albopictus is a vector of arboviruses that cause severe diseases in humans such as Chikungunya, Dengue and Zika fevers. The vector competence of Ae. albopictus varies depending on the mosquito population involved and the virus transmitted. Wolbachia infection status in believed to be among key elements that determine viral transmission efficiency. Little is known about the cellular functions mobilized in Ae. albopictus during co-infection by Wolbachia and a given arbovirus. To decipher this tripartite interaction at the molecular level, we performed a proteome analysis in Ae. albopictus C6/36 cells mono-infected by Wolbachia wAlbB strain or Chikungunya virus (CHIKV), and bi-infected.
resultsWe first confirmed significant inhibition of CHIKV by Wolbachia. Using two-dimensional gel electrophoresis followed by nano liquid chromatography coupled with tandem mass spectrometry, we identified 600 unique differentially expressed proteins mostly related to glycolysis, translation and protein metabolism. Wolbachia infection had greater impact on cellular functions than CHIKV infection, inducing either up or down-regulation of proteins associated with metabolic processes such as glycolysis and ATP metabolism, or structural glycoproteins and capsid proteins in the case of bi-infection with CHIKV. CHIKV infection inhibited expression of proteins linked with the processes of transcription, translation, lipid storage and miRNA pathways.
conclusionsThe results of our proteome profiling have provided new insights into the molecular pathways involved in tripartite Ae. albopictus-Wolbachia-CHIKV interaction and may help defining targets for the better implementation of Wolbachia-based strategies for disease transmission control.
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