ArticleMolecular cell2017
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.
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Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
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Who cites it
81 citing papers in PubMed, 131 citations in OpenAlex.
- Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells.Molecular biomedicine · 2025Article
- Enhancing Late-Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels.Aging cell · 2025Article
- Targeting mitochondrial dysfunction to intervene in liver cancer.Cancer biology & medicine · 2025Review
- Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.European journal of heart failure · 2025Review
- Mitochondrial CaJournal of cellular physiology · 2025Review
- Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.Circulation research · 2025Article
- The roles of mitochondria in global and local intracellular calcium signalling.Nature reviews. Molecular cell biology · 2025Review
- Mitochondrial CaCell reports · 2025Article
- Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multiple Inhibitory Mechanisms of DS16570511 Targeting Mitochondrial Calcium Uptake: Insights from Biochemical Analysis of Rat Liver Mitochondria.International journal of molecular sciences · 2025Article
- Mitochondrial calcium uniporter complex: An emerging therapeutic target for cardiovascular diseases (Review).International journal of molecular medicine · 2025Review
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- Breast cancer cells utilize T3 to trigger proliferation through cellular CaCell communication and signaling : CCS · 2024Article
- Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks.The EMBO journal · 2024Article
- Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments.PLoS biology · 2024Article
- Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium.Cancer discovery · 2024Article
- The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off-target effects.British journal of pharmacology · 2024Article
- Supramolecular delivery of dinuclear ruthenium and osmium MCU inhibitors.Inorganic chemistry frontiers · 2024Article
- Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling.Cardiovascular diabetology · 2024Article
- [Liver cancer treatment with mitochondrial homeostasis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Daniela M ArduinoGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Jennifer WettmarshausenGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Horia VaisDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Paloma Navas-NavarroInstituto de Biología y Genética Molecular (IBGM), University of Valladolid and Consejo Superior de Investigaciones Científicas (CSIC), Valladolid 47003, Spain.
Yiming ChengGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Anja LeimpekGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Zhongming MaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alba Delrio-LorenzoInstituto de Biología y Genética Molecular (IBGM), University of Valladolid and Consejo Superior de Investigaciones Científicas (CSIC), Valladolid 47003, Spain.
Andrea GiordanoGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Cecilia Garcia-PerezGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Guillaume MédardChair for Proteomics and Bioanalytics, Technical University Munich, Freising 85354, Germany.
Bernhard KusterChair for Proteomics and Bioanalytics, Technical University Munich, Freising 85354, Germany; Center for Integrated Protein Science Munich, Freising 85354, Germany.
Javier García-SanchoInstituto de Biología y Genética Molecular (IBGM), University of Valladolid and Consejo Superior de Investigaciones Científicas (CSIC), Valladolid 47003, Spain.
Dejana MokranjacBiomedical Center, Department of Physiological Chemistry, Ludwig-Maximilians Universität München, Martinsried 81377, Germany.
J Kevin FoskettDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
M Teresa AlonsoInstituto de Biología y Genética Molecular (IBGM), University of Valladolid and Consejo Superior de Investigaciones Científicas (CSIC), Valladolid 47003, Spain.
Fabiana PerocchiGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich 81377, Germany; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany. Electronic address: perocchi@genzentrum.lmu.de.
Helmholtz Zentrum München · DEUniversidad de Valladolid · ESUniversity of Pennsylvania · USCenter for Integrated Protein Science Munich · DELudwig-Maximilians-Universität München · DE
Funding
Electrophysiology of nuclear membrane InsP3 receptorR37GM056328 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2011 to 2020
$4.9MELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTORR01GM056328 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 1999 to 2010
$4.2MRole of CALHM1 ion channel in taste transductionR01DC012538 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2013 to 2017
$1.7MNIDCD NIH HHS R01 DC012538NIGMS NIH HHS R01 GM056328NIGMS NIH HHS R37 GM056328
Abstract
The mitochondrial calcium uniporter complex is essential for calcium (Ca
Indexed as
High-Throughput Screening AssaysAequorinAnimalsCalciumCalcium Channel BlockersCalcium ChannelsDose-Response Relationship, DrugDrug DiscoveryEnergy MetabolismHEK293 CellsHeLa CellsHumansKineticsLactic AcidMannitolMembrane PotentialsAequorinCalciumCalcium Channel BlockersCalcium ChannelsLactic AcidMannitolmitochondrial calcium uniporterMitoxantroneSMDT1 protein, humanSucrosebioenergeticscalciumcalcium signalingdrug discoverydrug screeninghigh-throughput screeningMCUmitochondriamitochondrial calcium uniporter
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.