Trial reportPloS one2017
Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial.
Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00116194 (Physical Exercise to Prevent Disability Pilot Study), which is not on this map. Cited by 89 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Exercise to Prevent Disability Pilot Study
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Community-based interventions to support aging in place and functional independence in older adults: a systematic review of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Impact of physical activity and exercise training on health-related quality of life in older adults: an umbrella review.GeroScience · 2025Pooled it
- A systematic review and meta-analysis of the long-term effects of physical activity interventions on objectively measured outcomes.BMC public health · 2023Pooled it
- Long-Term Exposure to Residential Greenspace and Healthy Ageing: a Systematic Review.Current environmental health reports · 2020Pooled it
- Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Effect of Intrapersonal and Interpersonal Behavior Change Strategies on Physical Activity Among Older Adults: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Trial
- Effects of Activity Tracker Use With Health Professional Support or Telephone Counseling on Maintenance of Physical Activity and Health Outcomes in Older Adults: Randomized Controlled Trial.JMIR mHealth and uHealth · 2021Trial
- Trial
- Relationships Between Profiles of Physical Activity and Major Mobility Disability in the LIFE Study.Journal of the American Geriatrics Society · 2020Trial
- Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.Journal of the American Geriatrics Society · 2020Trial
- Physical Performance and Vitamin D in Elderly Black Women-The PODA Randomized Clinical Trial.The Journal of clinical endocrinology and metabolism · 2019Trial
- Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.Journal of the American Geriatrics Society · 2018Trial
- Association between physical activity bout length and physical functioning in older adults using absolute and relative intensity thresholds: a longitudinal cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Effectiveness of mobile health interventions on physical activity management in frail older adults: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Review
- Association between physical activity levels and motoric cognitive risk syndrome in Chinese older adults.BMC geriatrics · 2026Article
- Mediating pathways of physical capabilities: linking perceived physical fatigability to motoric cognitive risk syndrome in community older adults.BMC geriatrics · 2026Article
- From Lifespan to Healthspan: Integrating Nutrition and Physical Activity in Healthy Ageing.Nutrients · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2.6 years. 1,635 sedentary men and women aged 70-89 years who had functional limitations were randomized to a structured moderate intensity walking, resistance, and flexibility physical activity program or a health education program. Physical activity dose was assessed by 7-day accelerometry and self-report at baseline and 24 months. Outcomes included the 400 m walk gait speed, the Short Physical Performance Battery (SPPB), assessed at baseline, 6, 12, and 24 months, and onset of major mobility disability (objectively defined by loss of ability to walk 400 m in 15 min). When the physical activity arm or the entire sample were stratified by change in physical activity from baseline to 24 months, there was a dose-dependent increase in the change in gait speed and SPPB from baseline at 6, 12, and 24 months. In addition, the magnitude of change in physical activity over 24 months was related to the reduction in the onset of major mobility disability (overall P < 0.001) (highest versus the lowest quartile of physical activity change HR 0.23 ((95% CI:0.10-0.52) P = 0.001) in the physical activity arm. We observed a dose-dependent effect of objectively monitored physical activity on physical functioning and onset of major mobility disability. Relatively small increases (> 48 minutes per week) in regular physical activity participation had significant and clinically meaningful effects on these outcomes.
trial registrationClinicalsTrials.gov NCT00116194.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.