Evidence map›Paper›PMID 28820869›Full record

ArticlePediatric research2018

Necrotizing enterocolitis and high intestinal iron uptake due to genetic variants.

Wolfgang Göpel, Josephine Drese, Tanja K Rausch, Nele Twisselmann, Bettina Bohnhorst, Andreas Müller, Axel Franz, Andreas Ziegler, Christoph Härtel, Egbert Herting

Open access · bronzeAbstract read
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In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Cell death of intestinal epithelial cells in intestinal diseases.Sheng li xue bao : [Acta physiologica Sinica] · 2020
    Review
  3. Precision Nutrition in Chronic Inflammation.Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Wolfgang GöpelDepartment of Pediatrics, University of Lübeck, UKSH, Lübeck, Germany.
Josephine DreseDepartment of Pediatrics, University of Lübeck, UKSH, Lübeck, Germany.
Tanja K RauschInstitute for Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.
Nele TwisselmannDepartment of Pediatrics, University of Lübeck, UKSH, Lübeck, Germany.
Bettina BohnhorstDepartment of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany.
Andreas MüllerDepartment of Pediatrics, University of Bonn, Bonn, Germany.
Axel FranzDepartment of Neonatology, University Children Hospital, Tübingen, Germany.
Andreas ZieglerStatSol, Moenring 2, Lübeck, Germany.
Christoph HärtelDepartment of Pediatrics, University of Lübeck, UKSH, Lübeck, Germany.
Egbert HertingDepartment of Pediatrics, University of Lübeck, UKSH, Lübeck, Germany.
University of Lübeck · DEUniversity of Bonn · DEMedizinische Hochschule Hannover · DEUniversity Children's Hospital Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundIntestinal iron is a nutritional compound, which is essential for enteric microbiota. We evaluated the hypothesis that polymorphisms, which are known modifiers of intestinal iron uptake in adults, are associated with necrotizing enterocolitis (NEC) in preterm infants.MethodsPreterm infants (birth weight below 1,500 g) were studied. Single-nucleotide polymorphisms with known effects on serum iron levels (rs1800562, rs1799945, and rs855791) were determined using PCR. The effects of polymorphisms on NEC surgery were tested by Mendelian randomization. Outcome data were compared with χ

Indexed as

AllelesEnterocolitis, NecrotizingFollow-Up StudiesGenetic VariationGenotypeGermanyHemochromatosis ProteinHumansInfant, NewbornInfant, PrematureIntestinal PerforationIronMembrane ProteinsMendelian Randomization AnalysisMicrobiotaPolymorphism, Single NucleotideHemochromatosis ProteinHFE protein, humanIronMembrane ProteinsSerine EndopeptidasesTMPRSS6 protein, human

Identifiers

PMID28820869
OpenAlexW2748815316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.