ArticleeLife2017
A lncRNA fine tunes the dynamics of a cell state transition involving
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
What it found
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Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanisms coordinating exit from the stem cell state in mammals.Genes & development · 2026Review
- Widespread DNA off-targeting confounds RNA chromatin occupancy studies.Nature biotechnology · 2026Article
- Scaling and self-similarity in the formation of the embryonic epigenome.Nature physics · 2026Article
- Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation.Mobile DNA · 2025Review
- Claudin-6 mediates an embryonic stem cell-driven antitumor response against breast cancer.iScience · 2025Article
- Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit.Science China. Life sciences · 2024Article
- Malat1 affects transcription and splicing through distinct pathways in mouse embryonic stem cells.NAR genomics and bioinformatics · 2024Article
- Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.Molecular cell · 2024Article
- SRRM2 splicing factor modulates cell fate in early development.Biology open · 2024Article
- A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control.Frontiers in cell and developmental biology · 2024Article
- Dysregulation of murine long noncoding single-cell transcriptome in nonalcoholic steatohepatitis and liver fibrosis.RNA (New York, N.Y.) · 2023Article
- RNA-Chrom: a manually curated analytical database of RNA-chromatin interactome.Database : the journal of biological databases and curation · 2023Article
- Epigenetics as "conductor" in "orchestra" of pluripotent states.Cell and tissue research · 2022Review
- LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond.Journal of experimental & clinical cancer research : CR · 2022Review
- Regulation of Chromatin Organization in Cell Stemness: The Emerging Role of Long Non-coding RNAs.Stem cell reviews and reports · 2021Review
- Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs.Nucleic acids research · 2021Article
- The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner.Science advances · 2021Article
- Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.Scientific reports · 2021Article
- Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation.Cell death & disease · 2020Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Meng Amy LiWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-6619-9919
Paulo P AmaralThe Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Priscilla CheungDivision of Cellular and Developmental Biology, Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, United States.
Jan H BergmannCold Spring Harbor Laboratory, Cold Spring Harbor, United States.
Masaki KinoshitaWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Tüzer KalkanWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Meryem RalserWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Sam RobsonThe Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Ferdinand von MeyennBabraham Institute, Cambridge, United Kingdom.
Maike ParamorWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Fengtang YangWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Caifu ChenIntegrated DNA Technologies, Redwood, United States.
Jennifer NicholsWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
David L SpectorCold Spring Harbor Laboratory, Cold Spring Harbor, United States.
Tony KouzaridesThe Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Lin HeDivision of Cellular and Developmental Biology, Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, United States.
Austin SmithWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3029-4682
Wellcome/MRC Cambridge Stem Cell Institute · GBUniversity of Cambridge · GBCold Spring Harbor Laboratory · USUniversity of California, Berkeley · USBabraham Institute · GBIntegrated DNA Technologies (United States) · USWellcome Sanger Institute · GB
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MVIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8MmiR-200 miRNAs repress tumor metastasis in lung adenocarcinomaR01CA139067 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2009 to 2021
$3.3MA new technology to isolate RNP complexes of a polycistronic miRNA oncogeneR21CA175560 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2013 to 2014
$360kBiotechnology and Biological Sciences Research Council BB/M004023/1Cancer Research UK 10827Cancer Research UK 17001Cancer Research UK C6946/A14492Cancer Research UK C6/A18796Medical Research Council G1100526Medical Research Council MC_PC_12009NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA139067NCI NIH HHS R21 CA175560Wellcome TrustWellcome Trust 091484/Z/10/ZWellcome Trust 092096Wellcome Trust 096125/Z/11/Z
Abstract
Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rodent-specific long non-coding RNA (lncRNA)
Indexed as
Cell DifferentiationDNA MethylationGene Expression RegulationAnimalsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BGene DeletionMiceMicroRNAsMouse Embryonic Stem CellsRNA-Binding ProteinsRNA, Long NoncodingDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDnmt3a protein, mouseLin-28 protein, mouseMicroRNAsmirnlet7 microRNA, mouseRNA-Binding ProteinsRNA, Long Noncodingde novo DNA methylationdevelopmental biologyLin28a/Mirlet7long non-coding RNAmousepluripotencystem cellsstem cell transition
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.