ArticleThe American journal of tropical medicine and hygiene2017
The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis.
Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Transdifferentiation of neutrophils facilitates the establishment of infection byInfection and immunity · 2025Article
- The roles of arginases and arginine in immunity.Nature reviews. Immunology · 2025Review
- Contrasting Phenotypes of Neutrophils During Asymptomatic Versus Symptomatic Leishmania braziliensis Infection.The Journal of infectious diseases · 2024Article
- Immune response to viscerotropicFrontiers in immunology · 2024Review
- MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis.Frontiers in immunology · 2024Article
- Evaluation of Proinflammatory Chemokines in HIV Patients with AsymptomaticTropical medicine and infectious disease · 2023Article
- Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response toFrontiers in immunology · 2021Article
- The Impact of Neutrophil Recruitment to the Skin on the Pathology Induced byFrontiers in immunology · 2021Review
- An Attempt to Polarize Human Neutrophils Toward N1 and N2 PhenotypesFrontiers in immunology · 2020Article
- HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis.Immunology · 2019Article
- Different Faces for Different Places: Heterogeneity of Neutrophil Phenotype and Function.Journal of immunology research · 2019Review
- The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Visceral leishmaniasis (VL) is a chronic parasitic disease associated with suppressed T cell responses. Although parasites reside intracellularly in macrophages during chronic VL, neutrophils are the first host cell to infiltrate the infection site and phagocytose the parasite. Subsets of neutrophils with unusual characteristics have been documented in human VL, but whether the total neutrophil population is aberrant during disease is not known. Therefore, we examined phenotypic characteristics of unfractionated polymorphonuclear leukocyte (neutrophils) from subjects with active VL, and compared these with neutrophils from healthy controls or subjects who have been treated for VL. The data showed decreased mRNA and diminished amounts of the neutrophil chemoattractant CXCL8 (interleukin [IL]-8), increased IL-10 mRNA and protein, and elevated transcripts encoding arginase-1, which is involved in suppressing T cell responses. Neutrophils from VL subjects showed enhanced capacity to phagocytose
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.