ArticleSensors (Basel, Switzerland)2017
A Third Generation Glucose Biosensor Based on Cellobiose Dehydrogenase Immobilized on a Glassy Carbon Electrode Decorated with Electrodeposited Gold Nanoparticles: Characterization and Application in Human Saliva.
Article in Sensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 95 citations in OpenAlex.
- Enzyme Co-Immobilization on Precipitated Silica for Sustainable Lactobionic Acid Production.Molecules (Basel, Switzerland) · 2026Article
- Control of sensitivity in metal oxide electrolyte gated field-effect transistor-based glucose sensor by electronegativity modulation.Scientific reports · 2024Article
- Planar Disk μ-Aptasensors by Monolayer Assembly in a Dissolving Microdroplet.Analytical chemistry · 2024Article
- Recent Insights into Glucose-Responsive Concanavalin A-Based Smart Hydrogels for Controlled Insulin Delivery.Gels (Basel, Switzerland) · 2024Review
- Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus.ADMET & DMPK · 2024Review
- Carbon nanotubes: a powerful bridge for conductivity and flexibility in electrochemical glucose sensors.Journal of nanobiotechnology · 2023Review
- Insight into continuous glucose monitoring: from medical basics to commercialized devices.Mikrochimica acta · 2023Review
- Redox-Mediated Gold Nanoparticles with Glucose Oxidase and Egg White Proteins for Printed Biosensors and Biofuel Cells.International journal of molecular sciences · 2023Article
- Smart Graphene-Based Electrochemical Nanobiosensor for Clinical Diagnosis: Review.Sensors (Basel, Switzerland) · 2023Review
- Progress of Enzymatic and Non-Enzymatic Electrochemical Glucose Biosensor Based on Nanomaterial-Modified Electrode.Biosensors · 2022Review
- High-Linearity Hydrogel-Based Capacitive Sensor Based onPolymers · 2022Article
- Versatile potentiometric metabolite sensing without dioxygen interference.Biosensors & bioelectronics · 2022Article
- Bio-fabrication of thermozyme-based nano-biosensors: their components and present scenario.Journal of materials science. Materials in electronics · 2022Article
- Label Free Glucose Electrochemical Biosensor Based on Poly(3,4-ethylenedioxy thiophene):Polystyrene Sulfonate/Titanium Carbide/Graphene Quantum Dots.Biosensors · 2021Article
- Oxidase-loaded hydrogels for versatile potentiometric metabolite sensing.Biosensors & bioelectronics · 2021Article
- Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production.Biology · 2021Review
- Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables.Frontiers in bioengineering and biotechnology · 2021Review
- Development of an Electrochemical Immunosensor for Specific Detection of Visceral Leishmaniasis Using Gold-Modified Screen-Printed Carbon Electrodes.Biosensors · 2020Article
- Enzyme-Based Biosensors: Tackling Electron Transfer Issues.Sensors (Basel, Switzerland) · 2020Review
- Porous Gold: A New Frontier for Enzyme-Based Electrodes.Nanomaterials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient direct electron transfer (DET) between a cellobiose dehydrogenase mutant from Corynascus thermophilus (CtCDH C291Y) and a novel glassy carbon (GC)-modified electrode, obtained by direct electrodeposition of gold nanoparticles (AuNPs) was realized. The electrode was further modified with a mixed self-assembled monolayer of 4-aminothiophenol (4-APh) and 4-mercaptobenzoic acid (4-MBA), by using glutaraldehyde (GA) as cross-linking agent. The CtCDH C291Y/GA/4-APh,4-MBA/AuNPs/GC platform showed an apparent heterogeneous electron transfer rate constant (ks) of 19.4 ± 0.6 s-1, with an enhanced theoretical and real enzyme surface coverage (Γtheor and Γreal) of 5287 ± 152 pmol cm-2 and 27 ± 2 pmol cm-2, respectively. The modified electrode was successively used as glucose biosensor exhibiting a detection limit of 6.2 μM, an extended linear range from 0.02 to 30 mM, a sensitivity of 3.1 ± 0.1 μA mM-1 cm-2 (R2 = 0.995), excellent stability and good selectivity. These performances compared favourably with other glucose biosensors reported in the literature. Finally, the biosensor was tested to quantify the glucose content in human saliva samples with successful results in terms of both recovery and correlation with glucose blood levels, allowing further considerations on the development of non-invasive glucose monitoring devices.
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