Evidence map›Paper›PMID 28820316›Full record

ArticleCell cycle (Georgetown, Tex.)2017

Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line.

Chiara Montemurro, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E Butler, Kenny E Vongbunyong, Anton Petcherski, Orian S Shirihai, Leslie S Satin, Daniel Braas, Peter C Butler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chiara Montemurroa Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.ORCID http://orcid.org/0000-0002-7070-2724
Suryakiran Vadrevub Department of Pharmacology and Brehm Diabetes Research Center , University of Michigan , Ann Arbor , MI , USA.ORCID http://orcid.org/0000-0002-2372-1439
Tatyana Gurloa Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.
Alexandra E Butlera Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.
Kenny E Vongbunyonga Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.ORCID http://orcid.org/0000-0002-2852-4127
Anton Petcherskic Division of Endocrinology, Department of Medicine, David Geffen School of Medicine , University of California, Los Angeles , Los Angeles , CA , USA.
Orian S Shirihaic Division of Endocrinology, Department of Medicine, David Geffen School of Medicine , University of California, Los Angeles , Los Angeles , CA , USA.
Leslie S Satinb Department of Pharmacology and Brehm Diabetes Research Center , University of Michigan , Ann Arbor , MI , USA.
Daniel Braasd Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA ; UCLA Metabolomics Center , University of California, Los Angeles , Los Angeles , CA , USA.
Peter C Butlera Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.
Slavica Tudzarovaa Larry L. Hillblom Islet Research Center , University of California, Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
Role of IAPP in Islet Dysfunction in DiabetesR01DK059579 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUTLER, PETER CAWOOD · 2001 to 2019
$7.5M
Capacity and Mechanisms of Beta Cell Regeneration in HumansR01DK077967 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTLER, PETER CAWOOD · 2008 to 2016
$2.5M
Mitochondrial regulation of energy efficiencyR01DK099618 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 2014 to 2018
$1.8M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK046409NIDDK NIH HHS R01 DK059579NIDDK NIH HHS R01 DK077967NIDDK NIH HHS R01 DK099618
6 · The paper itself

Abstract

Cell replication is a fundamental attribute of growth and repair in multicellular organisms. Pancreatic beta-cells in adults rarely enter cell cycle, hindering the capacity for regeneration in diabetes. Efforts to drive beta-cells into cell cycle have so far largely focused on regulatory molecules such as cyclins and cyclin-dependent kinases (CDKs). Investigations in cancer biology have uncovered that adaptive changes in metabolism, the mitochondrial network, and cellular Ca

Indexed as

AnimalsCell CycleCell DivisionCell LineCyclin-Dependent KinasesCyclinsDNA ReplicationInsulin-Secreting CellsMitochondriaMitochondrial DynamicsRatsCyclin-Dependent KinasesCyclinsbeta-cellcalciumcell cycleglucose metabolismmitochondria

Identifiers

PMID28820316
PMCPMC5731404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.