Evidence map›Paper›PMID 28820033›Full record

ArticlePerfusion2017

Unregulated saphenous vein graft distension decreases tissue viscoelasticity.

Eric S Wise, Kyle M Hocking, Brian C Evans, Craig L Duvall, Joyce Cheung-Flynn, Colleen M Brophy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eric S Wise1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kyle M Hocking1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brian C Evans1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Craig L Duvall3 Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Joyce Cheung-Flynn1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Colleen M Brophy1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

PREVENTION OF VEIN GRAFT SPASMR01HL070715 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROPHY, COLLEEN M · 2003 to 2021
$7.2M
MK2 Inhibitory Nanoplexes to Enhance Long-Term Vascular Graft PatencyR01HL122347 · NHLBI · VANDERBILT UNIVERSITY · PI DUVALL, CRAIG LEWIS · 2016 to 2020
$2.2M
Methods To Reduce Vein Harvest InjuryR01HL105731 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHEUNG-FLYNN, JOYCE · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL070715NHLBI NIH HHS R01 HL105731NHLBI NIH HHS R01 HL122347
6 · The paper itself

Abstract

objectivesUnregulated intraoperative distension of human saphenous vein (SV) graft leads to supraphysiologic luminal pressures and causes acute physiologic and cellular injury to the conduit. The effect of distension on tissue viscoelasticity, a biophysical property critical to a successful graft, is not well described. In this investigation, we quantify the loss of viscoelasticity in SV deformed by distension and compare the results to tissue distended in a pressure-controlled fashion. MATERIALS AND

methodsUnmanipulated porcine SV was used as a control or distended without regulation and distended with an in-line pressure release valve (PRV). Rings were cut from these tissues and suspended on a muscle bath. Force versus time tracings of tissue constricted with KCl (110 mM) and relaxed with sodium nitroprusside (SNP) were fit to the Hill model of viscoelasticity, using mean absolute error (MAE) and r

resultsOne-way ANOVA analysis demonstrated that, in tissue distended manually, the MAE was significantly greater and the r

conclusionsUnregulated manual distension of SV graft causes loss of viscoelasticity and such loss may be mitigated with the use of an in-line PRV.

Indexed as

AnimalsCoronary Artery BypassEndothelium, VascularHumansSaphenous VeinSwineVasoconstrictionbypass graftsdistensionsaphenous veinvasoconstrictionviscoelasticity

Identifiers

PMID28820033
PMCPMC5967241
OpenAlexW2591807976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.