ReviewJournal of endocrinological investigation2018
Polyglandular autoimmune syndromes.
Review in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Pooled it
- Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III.Journal of endocrinological investigation · 2020Pooled it
- Under-recognition of autoimmune polyendocrine syndromes in T1DM: results from an extended screening workup.Endocrine · 2026Article
- Addison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.JCEM case reports · 2026Article
- Beyond Type 1 Diabetes: Autoimmune Gastritis-Driven Multisystem Disease in Autoimmune Polyglandular Syndrome Type 3.Cureus · 2026Article
- Type 1 Diabetes and Other Autoimmune Diseases-Epidemiology, Pathophysiology and Screening.Endocrinology, diabetes & metabolism · 2026Review
- Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity.Frontiers in endocrinology · 2026Article
- A case-control study on autoimmune polyendocrine syndromes in patients with systemic lupus erythematosus.Rheumatology (Oxford, England) · 2025Article
- A Case of Autoimmune Polyglandular Syndrome Type 2 in Childhood: Unraveling a Rare and Complex Endocrine Puzzle.Cureus · 2025Article
- Clinical and serological characteristics of type 3 APS, isolated T1DM and LADY/LADA.BMC endocrine disorders · 2025Article
- Systematic Analysis and Network Mapping of Disease Associations in Autoimmune Polyglandular Syndrome.The Journal of clinical endocrinology and metabolism · 2025Article
- Autoimmune polyendocrine syndrome type 2 in children: a case report and literature review.BMC pediatrics · 2025Review
- Diverse clinical manifestations and management strategies in autoimmune polyglandular syndrome: a review of cases.Annals of medicine and surgery (2012) · 2025Review
- Autoimmune polyglandular syndrome among Chinese celiac disease patients: a survey of 243 individuals in China.Frontiers in immunology · 2025Article
- Association of maternal thyroid function and gestational diabetes with pregnancy outcomes: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Cemiplimab and diabetic ketoacidosis: a case report of a rare endocrinopathy associated with immune checkpoint inhibitors.Frontiers in endocrinology · 2025Article
- Case Report: The potential association with polyglandular autoimmune syndrome in a dog following long-term oclacitinib therapy.Frontiers in veterinary science · 2025Article
- Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases.Burns & trauma · 2025Review
- Case Report: Autoimmune polyglandular syndrome type 4 involving diabetes mellitus type 1, autoimmune hepatitis, immune thrombocytopenia, and celiac disease.Frontiers in endocrinology · 2025Article
- Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics.EXCLI journal · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, scientific knowledge pertaining to the rare ORPHAN polyglandular autoimmune syndrome (registered code ORPHA 282196) has accumulated.
objectiveTo offer current demographic, clinical, serological and immunogenic data on PAS.
methodsReview of the pertinent and current literature.
resultsPolyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies. PAS show a great heterogeneity of syndromes and manifest sequentially with a large time interval between the occurrence of the first and second glandular autoimmune disease. PAS cluster with several non-endocrine autoimmune diseases. In most endocrinopathies of PAS, the autoimmune process causes an irreversible loss of function, while chronic autoimmune aggressions can simultaneously modify physiological processes in the affected tissue and lead to altered organ function. The rare juvenile PAS type I is inherited in a monogenetic manner, whereas several susceptibility gene polymorphisms have been reported for the more prevalent adult types. Relevant for a timely diagnosis at an early stage is the screening for polyglandular autoimmunity in patients with monoglandular autoimmune disease and/or first degree relatives of patients with PAS. The most prevalent adult PAS type is the combination of type 1 diabetes with autoimmune thyroid disease.
conclusionsEarly detection of specific autoantibodies and latent organ-specific dysfunction is advocated to alert physicians to take appropriate action in order to prevent full-blown PAS disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.