ReviewNeurosurgical review2019
Recurrence of endovascularly and microsurgically treated intracranial aneurysms-review of the putative role of aneurysm wall biology.
Review in Neurosurgical review, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Clinical outcomes of first- and second-generation hydrogel coils compared with bare platinum coils: a systematic literature review.Neurosurgical review · 2022Pooled it
- The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review.Neurosurgical review · 2022Pooled it
- Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent-Assisted Coil Embolization.Immunity, inflammation and disease · 2025Article
- A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Detection of remnants in clipped unruptured intracranial aneurysms by intraoperative CT-angiography and postoperative DSA: clinical relevance and follow-up.Acta neurochirurgica · 2025Article
- Quantitative TOF-MRA using SYNAPSE VINCENT predicts neointimal formation after stent-assisted coiling of intracranial aneurysms.Frontiers in neurology · 2025Article
- Endothelial Cell Transcription Modulation in Cerebral Aneurysms After Endovascular Flow Diversion.Annals of biomedical engineering · 2024Article
- The white-collar sign after Neuroform Atlas stent-assisted coil embolization of unruptured intracranial aneurysms.The neuroradiology journal · 2024Article
- Early vascular embolization improves neurological function in patients with intracranial aneurysm.American journal of translational research · 2024Article
- Topographic distribution of inflammation factors in a healing aneurysm.Journal of neuroinflammation · 2023Article
- Evaluation of short- and long-term results of Y-stent-assisted coiling with Leo stents in endovascular treatment of wide-necked intracranial bifurcation aneurysms.Neuroradiology · 2023Article
- Incidence rate and predictors of recurrent aneurysms after clipping: long-term follow-up study of survivors of subarachnoid hemorrhage.Neurosurgical review · 2022Article
- Efficacy and Safety of Different Bioactive Coils in Intracranial Aneurysm Interventional Treatment, a Systematic Review and Bayesian Network Meta-Analysis.Brain sciences · 2022Review
- Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2022Article
- Repeated Aneurysm Intervention.Advances and technical standards in neurosurgery · 2022Article
- Correlation Between Thrombus Signal Intensity and Aneurysm Wall Thickness in Partially Thrombosed Intracranial Aneurysms Using 7T Magnetization-Prepared Rapid Acquisition Gradient Echo Magnetic Resonance Imaging.Frontiers in neurology · 2022Article
- Bioactive refinement for endosaccular treatment of intracranial aneurysms.The neuroradiology journal · 2021Review
- Long non-coding RNA NORAD induces phenotypic regulation of vascular smooth muscle cells through regulating microRNA-136-5p-targeted KDM1A.Cell cycle (Georgetown, Tex.) · 2021Article
- Value of 3-Dimensional Digital Subtraction Angiography for Detection and Classification of Intracranial Aneurysm Remnants After Clipping.Operative neurosurgery (Hagerstown, Md.) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although endovascular therapy has been proven safe and has become in many centers the primary method of treatment for intracranial aneurysms, the long-term durability of endovascular embolization remains a concern; at least for some aneurysms despite initial good result. While healing after clipping relies on mechanical occlusion, restoration after endovascular occlusion mainly requires the induction of a biological response. Healing after embolization depends on the growth of new tissue over the thrombus formed by the embolization material, or alternatively, on the organization of thrombus into fibrous tissue. This review highlights the fundamental importance of aneurysm wall biology on the healing process and long-term occlusion after intracranial aneurysm (IA) treatment. It seems likely that the effect of luminal thrombus on the IA wall, as well as the IA wall condition at the time of thrombosis, determine if thrombus organizes into scar tissue (neointima formation by infiltration of cells originating from the IA wall) or if the wall undergoes continuous remodeling, which is primarily destructive (loss of mural cells). In the latter, intraluminal thrombus organization fails and the impaired healing increases the chance of recurrence. Mechanisms underlying IA reopening, the influence of intraluminal thrombosis on the IA wall, and clinical implications of the IA wall condition are discussed in detail, along with how knowledge of IA wall biology can offer new solutions for IA treatment and affect the patient selection for and follow-up after endovascular treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.