Evidence map›Paper›PMID 28819816›Full record

ArticleAmino acids2017

A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.

Myung Hee Park, Ajeet Mandal, Swati Mandal, Edith C Wolff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. The hypusine pathway inFrontiers in cellular and infection microbiology · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Myung Hee ParkNational Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, 20892-4340, USA. mhpark@nih.gov.
Ajeet MandalNational Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, 20892-4340, USA.
Swati MandalNational Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, 20892-4340, USA.
Edith C WolffNational Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, 20892-4340, USA.
National Institutes of Health · USNational Institute of Dental and Craniofacial Research · US

Funding

The Post-translational Synthesis of Hypusine In eIF5A and roles of eIF5A and polyamines in cell growth and animal developmentZIADE000608 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI PARK, MYUNG HEE · 2009 to 2021
$12.3M
THE POST-TRANSLATIONAL SYNTHESIS OF HYPUSINE IN EIF5A: DEOXYHYPUSINE SYNTHASEZ01DE000608 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI PARK, MYUNG HEE · 1994 to 2008
$1.6M
Intramural NIH HHS Z01 DE000608
6 · The paper itself

Abstract

Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N

Indexed as

Oxidoreductases Acting on CH-NH Group DonorsBiosynthetic PathwaysEnzyme AssaysEnzyme InhibitorsGuanineHigh-Throughput Screening AssaysHumansHydrogen-Ion ConcentrationKineticsLuminescent MeasurementsNADSmall Molecule LibrariesSpermidineSubstrate SpecificityTime Factorsdeoxyhypusine synthaseEnzyme InhibitorsGuanineN(1)-guanyl-1,7-diaminoheptaneNADOxidoreductases Acting on CH-NH Group DonorsSmall Molecule LibrariesSpermidineDeoxyhypusine synthaseeIF5AEnzyme assayHypusinePolyaminePost-translational modification

Identifiers

PMID28819816
PMCPMC5693660
OpenAlexW2750250921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.