ArticleJournal of neurology2017
Simultaneous EEG-PET-fMRI measurements in disorders of consciousness: an exploratory study on diagnosis and prognosis.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Multimodal prediction of residual consciousness in the intensive care unit: the CONNECT-ME study.Brain : a journal of neurology · 2023Trial
- Arterial Spin Labeling of Cerebral Perfusion in Unresponsive Wakefulness Syndrome: A Proof-of-Concept Comparison with FDG-PET.Neurocritical care · 2026Article
- [Guangdong consensus on integrated Chinese and Western medicine management of prolonged disorders of consciousness].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Multimodal multicentre investigation of diagnostic and prognostic markers in disorders of consciousness.Brain : a journal of neurology · 2026Article
- Prognostic factors in prolonged disorders of consciousness: a narrative review.Reviews in the neurosciences · 2026Review
- Multimodal PET/MR imaging of prolonged disorders of consciousness: a pilot feasibility study.Frontiers in neuroscience · 2026Article
- The Role of [Diagnostics (Basel, Switzerland) · 2025Review
- Protocol for Simultaneous EEG and fNIRS Measurement in Characterizing Brain State.Phenomics (Cham, Switzerland) · 2025Article
- Trimodal brain imaging: A novel approach for simultaneous investigation of human brain function.Biological psychology · 2025Review
- A study on resting-state functional near-infrared spectroscopy in patients with different outcomes of prolonged disorders of consciousness.Frontiers in neurology · 2025Article
- Local Neuronal Activity and the Hippocampal Functional Network Can Predict the Recovery of Consciousness in Individuals With Acute Disorders of Consciousness Caused by Neurological Injury.CNS neuroscience & therapeutics · 2024Article
- Transient brain activity dynamics discriminate levels of consciousness during anesthesia.Communications biology · 2024Article
- Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study.Frontiers in neurology · 2024Article
- Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness.NeuroImage · 2023Article
- Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic-Ischemic Brain Injury: A Pilot Study.Healthcare (Basel, Switzerland) · 2023Article
- Transitioning from PET/MR to trimodal neuroimaging: why not cover the temporal dimension with EEG?AIMS neuroscience · 2023Article
- Simultaneous EEG-fMRI: What Have We Learned and What Does the Future Hold?Sensors (Basel, Switzerland) · 2022Review
- Comparison of EEG microstates with resting state fMRI and FDG-PET measures in the default mode network via simultaneously recorded trimodal (PET/MR/EEG) data.Human brain mapping · 2021Article
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Brain network motif topography may predict emergence from disorders of consciousness: a case series.Neuroscience of consciousness · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies could demonstrate that functional magnetic resonance imaging (fMRI), fludeoxyglucose positron emission tomography (FDG-PET), and electroencephalography (EEG) measures contain information about patients suffering from disorders of consciousness (DOC) and thus improve the clinical diagnosis. Additionally, the technical modalities were able to predict the outcome of patients. However, most studies lack proven reproducibility in a clinical setting. We here applied a standardized combined EEG/fMRI/FDG-PET measurement to a cohort of 20 patients suffering from DOC and focused on parameters that have been demonstrated to contain information about diagnosis and prognosis of these patients. We evaluated EEG band power, fMRI connectivity in networks associated with consciousness and sensory networks, as well as absolute glucose uptake in the brain as potential markers of preserved consciousness or favorable outcome. Acquired data were analyzed by a principal component analysis to identify the most important markers in a hypothesis-free manner. These were then analyzed with statistical group comparisons. Absolute FDG-PET could prove that glucose metabolism in the occipital lobe is significantly higher in minimally conscious than in vegetative state patients. Delta band power showed to be prognostic marker for a favorable outcome. We conclude that absolute FDG-PET is a suitable tool to evaluate the level consciousness in DOC patients. Additionally, we propose delta band power as marker of a favorable outcome in DOC patients. We suggest that these findings promote a standardized technical evaluation of DOC patients to improve diagnosis and prognosis.
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