ArticleJournal of physiology and biochemistry2018
Maternal obesity is associated with gut microbial metabolic potential in offspring during infancy.
Article in Journal of physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity.BMC microbiology · 2024Pooled it
- Early Nutrition as a Modulator of Neurodevelopment via the Gut Microbiota in Preterm Neonates.Children (Basel, Switzerland) · 2026Review
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Burdock Tea Affects Pulmonary Microbiota and Physiology Through Short-Chain Fatty Acids in Wistar Rats.Biology · 2025Article
- Aromatics from fossil fuels and breast cancer.iScience · 2025Review
- Characterising glycosaminoglycans in human breastmilk and their potential role in infant health.Microbial cell (Graz, Austria) · 2024Article
- The infants' gut microbiome: setting the stage for the early onset of obesity.Frontiers in microbiology · 2024Article
- Impact of neonatal nutrition on necrotizing enterocolitis.Seminars in pediatric surgery · 2023Review
- Obesity, Gut Microbiota, and Metabolome: From Pathophysiology to Nutritional Interventions.Nutrients · 2023Review
- Maternal weight, gut microbiota, and the association with early childhood behavior: the PREOBE follow-up study.Child and adolescent psychiatry and mental health · 2023Article
- The Benefits of Switching to a Healthy Diet on Metabolic, Cognitive, and Gut Microbiome Parameters Are Preserved in Adult Rat Offspring of Mothers Fed a High-Fat, High-Sugar Diet.Molecular nutrition & food research · 2023Article
- Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis.Cancer reports (Hoboken, N.J.) · 2022Review
- Review
- Metagenomics and metabolomics analysis to investigate the effect of Shugan decoction on intestinal microbiota in irritable bowel syndrome rats.Frontiers in microbiology · 2022Article
- Different Weight Loss Intervention Approaches Reveal a Lack of a Common Pattern of Gut Microbiota Changes.Journal of personalized medicine · 2021Article
- Effect of host breeds on gut microbiome and serum metabolome in meat rabbits.BMC veterinary research · 2021Article
- Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point.Frontiers in cellular and infection microbiology · 2021Observational
- The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review.Nutrients · 2020Review
- Altered Gut Microbiota and Shift inBioMed research international · 2020Observational
- Effects of Maternal Low-Protein Diet on Microbiota Structure and Function in the Jejunum of Huzhu Bamei Suckling Piglets.Animals : an open access journal from MDPI · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Children born to obese mothers are at increased risk for obesity, but the mechanisms behind this association are not fully understood. Our study aimed to investigate differences in the functions encoded by the microbiome of infants at 18 months of age when the transition from early infant-feeding to solid family foods is established. To investigate the impact of maternal prepregnancy body mass index on infants' gut microbiome, faecal samples from infants born to normoweight (n = 21) and obese mothers (n = 18) were analysed by 16S rRNA gene sequencing and a functional-inference-based microbiome analysis. Our results indicated that Firmicutes was significantly enriched in infants born to normoweight mothers whereas Bacteroidetes was significantly enriched in infants born to obese women. In both microbiomes, the greatest number of genes (>50%) that were assigned a function encoded for proteins involved in "metabolism" among tier 1 KEGG Orthology (KO) categories. At lower KO functional categories, the microbiome of infants born to normoweight mothers was characterized by a significant enrichment in the abundances of "pentose phosphate pathway" (p = 0.037), "lysine biosynthesis" (p = 0.043), "glycerolipid metabolism" (p = 0.042), and "C5-branched dibasic acid metabolism" (p = 0.045). Notably, the microbiome of infants born to obese mothers was significantly enriched in "streptomycin biosynthesis" (p = 0.047), "sulphur metabolism" (p = 0.041), "taurine and hypotaurine metabolism" (p = 0.036), and "lipopolysaccharide biosynthesis" (p = 0.043). In summary, our study showed that maternal prepregnancy obesity may imprint a selective gut microbial composition during late infancy with distinct functional performances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.