Evidence map›Paper›PMID 28819713›Full record

ArticlePediatric cardiology2017

Plasma Growth Differentiation Factor-15 is a Potential Biomarker for Pediatric Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.

Gang Li, Yan Li, Xiao-Qiu Tan, Peng Jia, Jian Zhao, Dong Liu, Ting Wang, Bin Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  20. GDF-15 in Pulmonary and Critical Care Medicine.American journal of respiratory cell and molecular biology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gang LiDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Yan LiMedical Research Center, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Xiao-Qiu TanKey Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China.
Peng JiaDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Jian ZhaoDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Dong LiuDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Ting WangDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Bin LiuDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China. lblyfy@126.com.
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

Talent Foundation of Southwest Medical University 2016
6 · The paper itself

Abstract

We aimed to investigate plasma growth differentiation factor-15 (GDF-15) levels in pediatric pulmonary arterial hypertension secondary to congenital heart disease (PAH-CHD), and assess the association with hemodynamic parameters. Plasma GDF-15 levels were measured in children with PAH-CHD (n = 46) and compared to children with CHD without PAH (n = 39). Normal individuals (n = 30) served as health control group. Plasma GDF-15 levels were significantly elevated in patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, interquartile range [IQR] 926.7-2111.7 ng/L vs. 890.6 ng/L, IQR 394.7-1094.3 ng/L, p < 0.01). Elevated plasma GDF-15 levels were positively related to Functional Class, uric acid, N-terminal pro-B-type natriuretic peptide (NT-proBNP), pulmonary artery systolic pressure, mean pulmonary artery pressure, pulmonary blood flow/systemic blood flow and pulmonary vascular resistance, and a lower mixed venous oxygen saturation (Sv

Indexed as

Area Under CurveBiomarkersCardiac CatheterizationChildChild, PreschoolFemaleGrowth Differentiation Factor 15Heart Defects, CongenitalHemodynamicsHumansHypertension, PulmonaryInfantMaleNatriuretic Peptide, BrainPeptide FragmentsSensitivity and SpecificityBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)BiomarkerChildrenCongenital heart diseaseGrowth differentiation factor-15Pulmonary arterial hypertension

Identifiers

PMID28819713
OpenAlexW2747013209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.