ArticleNeuroradiology2017
Quantitative approach to the posterior cranial fossa and craniocervical junction in asymptomatic children with achondroplasia.
Article in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Volumetric segmentation in the context of posterior fossa-related pathologies: a systematic review.Neurosurgical review · 2024Pooled it
- Morphometric Analysis of the Openings in the Posterior Cranial Fossa and Their Relationship with Sex.Diagnostics (Basel, Switzerland) · 2025Article
- Posterior fossa decompression in syndromic children with chiari-like posterior fossa crowding: a nationwide US-based study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Comprehensive assessment of supratentorial and infratentorial volumes in infants with myelomeningocele with and without Chiari malformation type II.Neuroradiology · 2025Article
- Methodology for pediatric head computed tomography image segmentation and volumetric calculation using a tablet computer and stylus pen.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia.Journal of imaging · 2024Article
- Jugular foramen stenosis in external hydrocephalus in infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Extremely Preterm Infants with a Near-total Absence of Cerebellum: Usefulness of Quantitative Magnetic Resonance in Predicting the Motor Outcome.Cerebellum (London, England) · 2024Article
- Growth patterns and ratios of posterior cranial fossa structures in the Japanese pediatric population: a study utilizing CT scans.Neuroradiology · 2023Article
- Recommendations for neuroradiological examinations in children living with achondroplasia: a European Society of Pediatric Radiology and European Society of Neuroradiology opinion paper.Pediatric radiology · 2023Review
- European Achondroplasia Forum guiding principles for the detection and management of foramen magnum stenosis.Orphanet journal of rare diseases · 2023Article
- Thoracolumbar stenosis and neurologic symptoms: Quantitative MRI in achondroplasia.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Airways and craniofacial assessment in children affected by achondroplasia with and without sleep-disordered breathing: quantitative magnetic resonance study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Morphological Measurement and Anatomical Variations of the Clivus Using Computed Tomography.Journal of neurological surgery. Part B, Skull base · 2022Article
- New insights in craniovertebral junction MR changes leading to stenosis in children with achondroplasia.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia.Nature reviews. Endocrinology · 2022Review
- Functional and morphological changes in hypoplasic posterior fossa.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Pictorial review: imaging of the spinal manifestations of achondroplasia.The British journal of radiology · 2021Review
- Macrocerebellum in Achondroplasia: A Further CNS Manifestation ofAJNR. American journal of neuroradiology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe propose an magnetic resonance imaging (MRI)-based quantitative morphovolumetric approach to the posterior cranial fossa (PCF) and craniocervical junction (CCJ) changes in achondroplastic patients investigating possible associations with ventriculomegaly and medullary compression.
methodsWe analyzed MRI of 13 achondroplastic children not treated by surgery. 3D FSPGR T1-weighted images were used to analyze (1) PCF synchondroses; (2) PCF volume (PCFV), PCF brain volume (PCFBV), PCFV/PCFBV ratio, cerebellar volume, cerebrospinal fluid (CSF) spaces volume, and IV ventricle volume; (3) PCF (clivus, supraocciput, exocciput lengths, tentorial angle) and CCJ (AP and LL diameters of foramen magnum (FM)) morphometry; (4) measurements of FM and jugular foramina (JF) areas; and (5) supratentorial ventricular volume.
resultsAll patients showed synostosis of spheno-occipital synchondroses, eight showed synostosis of intra-occipital synchondroses, nine showed CCJ impingement on the cervical cord but only three had cervical myelopathy. Compared to controls, clivus and exocciput lengths, LL and AP diameters of FM, FM area and JF area were significantly reduced, supraocciput length, tentorial angle, PCFV, PCFBV, cerebellar volume, supratentorial ventricular system volume were significantly increased. A correlation was found between clivus length and supratentorial ventricular volume, premature closure of intra-occipital synchondroses and FM area while a trend was found between FM area and supraocciput length.
conclusionOur analysis demonstrates a relationship between the shortening of the clivus and the ventriculomegaly. On the other hand the premature closure of PCF synchondroses, the shape, and the growth direction of supraocciput bone contribute to reduce the FM area, causing in some patients medullary compression.
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