Evidence map›Paper›PMID 28819616›Full record

ArticleIranian journal of otorhinolaryngology2017

Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study.

Emmanuel Angulo-Castro, Luis F Acosta-Alfaro, Alma M Guadron-Llanos, Adrian Canizalez-Román, Fernando Gonzalez-Ibarra, Ignacio Osuna-Ramírez, Joel Murillo-Llanes

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of otorhinolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Environmental mechanisms of orofacial clefts.Birth defects research · 2020
    Review
  8. Article
  9. Article
  10. The Densitometric Analysis of Protein Pattern in Cleft Lip and Palate Patients.Journal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emmanuel Angulo-CastroDepartment of Perinatology, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.
Luis F Acosta-AlfaroDepartment of Perinatology, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.
Alma M Guadron-LlanosCIASaP, School of Medicine, Autonomous University of Sinaloa, 80246, Culiacan, Sinaloa, Mexico.
Adrian Canizalez-RománResearch Department, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.
Fernando Gonzalez-IbarraDepartment of Internal Medicine, Gulf Coast Medical Center, Panama City, 32405, Florida, USA.
Ignacio Osuna-RamírezFaculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, 80000 Culiacán, SIN, Mexico.
Joel Murillo-LlanesResearch Department, The Women's Hospital, Secretariat of Health, 80127, Culiacan, Sinaloa, Mexico.
Pediatric Hospital of Sinaloa · MXAutonomous University of Sinaloa · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. MATERIALS AND

methodsWe conducted a case control study at the Women's Hospital in Culiacan, Mexico. Medical records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015. Multiple variables were analyzed, including gestational age, weight at birth, the use of folic acid and multivitamins during pregnancy, smoking, alcohol abuse, the use of recreational drugs, history of sexually transmitted infections, marital status, socioeconomic status, education, and nutritional status.

resultsWe found that the maternal risk factors with the strongest association for the development of cleft lip and cleft palate were the following: patients who were not taking folic acid during pregnancy [OR 3.27, 95% CI 1.32-8.09], P=0.00; patients who were not taking vitamin supplementation during pregnancy [OR 2.6, 95% CI 1.19-7.27], P=0.02; smoking during pregnancy [OR 2.05, 95% CI 1.23-3.41], P=0.01; and alcohol abuse during pregnancy [OR 1.90, 95% CI 1.17-3.08], P=0.03.

conclusionsThe main risk factors associated with the development of cleft lip and cleft palate in a Mexican population at the Women's hospital in Culiacan, Sinaloa, Mexico were smoking, alcohol abuse, and patients not taking folic acid and multivitamins during pregnancy.

Indexed as

Cleft lipCleft palatePregnancy Complications

Identifiers

PMID28819616
PMCPMC5554809
OpenAlexW2739101272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.