Evidence map›Paper›PMID 28819394›Full record

ArticleJournal of Cancer2017

A Role for The ATP7A Copper Transporter in Tumorigenesis and Cisplatin Resistance.

Sha Zhu, Vinit Shanbhag, Yanfang Wang, Jaekwon Lee, Michael Petris

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 67 citations in OpenAlex.

  1. A broad-spectrum inhibitor of copper-exporting PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. A First-In-Class Broad Spectrum Inhibitor of Copper Exporting PbioRxiv : the preprint server for biology · 2026
    Article
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  18. Copper in the tumor microenvironment and tumor metastasis.Journal of clinical biochemistry and nutrition · 2022
    Article
  19. Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted.International journal of molecular sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sha ZhuDepartment of Biochemistry, University of Missouri, Columbia, MO, 65211.
Vinit ShanbhagDepartment of Biochemistry, University of Missouri, Columbia, MO, 65211.
Yanfang WangNutrition and Exercise Physiology, University of Missouri, Columbia, MO, 65211.
Jaekwon LeeRedox Biology Center, Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, 68588.
Michael PetrisDepartment of Biochemistry, University of Missouri, Columbia, MO, 65211.
University of Missouri · USUniversity of Nebraska–Lincoln · US

Funding

Tissue-specific pathways of copper homeostasis in growth and developmentR01DK093386 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2011 to 2016
$2.3M
Mechanistic insights into homeostatic copper acquistionR01DK079209 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI LEE, JAEKWON · 2007 to 2014
$1.9M
Copper metabolism as a unique vulnerability in cancerR01CA190265 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA190265NIDDK NIH HHS R01 DK079209NIDDK NIH HHS R01 DK093386
6 · The paper itself

Abstract

The ATP7A protein is a ubiquitously expressed copper-translocating P-type ATPase that controls cytoplasmic copper concentrations by mediating cellular copper egress.

Indexed as

ATP7ACisplatin resistanceCopper transporterTumorigenesis

Identifiers

PMID28819394
PMCPMC5559955
OpenAlexW2734515731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.