Evidence map›Paper›PMID 28819330›Full record

ArticleJournal of heterocyclic chemistry2017

Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.

Ruben S Vardanyan, James P Cain, Saghar Mowlazadeh Haghighi, Vlad K Kumirov, Mary I McIntosh, Alexander J Sandweiss, Frank Porreca, Victor J Hruby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of heterocyclic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruben S VardanyanDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, US.
James P CainDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, US.
Saghar Mowlazadeh HaghighiDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, US.
Vlad K KumirovDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, US.
Mary I McIntoshDepartment of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
Alexander J SandweissDepartment of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
Frank PorrecaDepartment of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
Victor J HrubyDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, US.
University of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NCI NIH HHS P30 CA023074NIDA NIH HHS DA06789NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

Several studies have suggested functional association between μ-opioid and δ-opioid receptors and showed that μ-activity could be modulated by δ-ligands. The general conclusion is that agonists for the δ-receptor can enhance the analgesic potency and efficacy of μ-agonists. Our preliminary investigations demonstrate that new bivalent ligands constructed from the μ-agonist fentanyl and the δ-agonist enkephalin-like peptides are promising entities for creation of new analgesics with reduced side effects for treatment of neuropathic pain. A new superposition of the mentioned pharmacophores led to novel μ-bivalent/δ-bivalent compounds that demonstrate both μ-opioid and δ-opioid receptor agonist activity and high efficacy in anti-inflammatory and neuropathic pain models with the potential of reduced unwanted side effects.

Identifiers

PMID28819330
PMCPMC5557416
OpenAlexW2473565908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.