Evidence map›Paper›PMID 28819309›Full record

ArticleScientific reports2017

Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography.

Joseph C Jing, Jason J Chen, Lidek Chou, Brian J F Wong, Zhongping Chen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Optica · 2023
    Article
  15. Phase-resolved dynamic wavefront imaging of cilia metachronal waves.Quantitative imaging in medicine and surgery · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Light-sheet laser speckle imaging for cilia motility assessment.Computational and structural biotechnology journal · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph C JingBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, 92617, CA, USA.ORCID 0000-0002-1283-3232
Jason J ChenBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, 92617, CA, USA.
Lidek ChouBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, 92617, CA, USA.
Brian J F WongBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, 92617, CA, USA.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, 92617, CA, USA. z2chen@uci.edu.
University of California, Irvine · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Elastographic Imaging of the Retina/Choroid in Age-Related Macular DegenerationR01EY021529 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, ZHONGPING, SILVERMAN, RONALD H · 2012 to 2015
$1.4M
NEI NIH HHS R01 EY021529NEI NIH HHS R01 EY026091NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

Ciliary motion plays a critical role in the overall respiratory health of the upper airway. These cilia beat at a native frequency and in a synchronized pattern to continuously transport foreign particulate trapped in a layer of mucous out of the upper airway. Disruption of ciliary motion can lead to severe respiratory diseases and compromised respiratory function. Currently, the study of cilia requires expensive high speed cameras and high powered microscopes which is unsuitable for in vivo imaging and diagnosis. Doppler based optical coherence tomography has the potential to visualize the microscopic motion of cilia during their beating cycle. We demonstrate the development of a high-speed Doppler optical coherence tomography system that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cilia function.

Indexed as

MotionPeriodicityAnimalsCiliaMaleRabbitsRespiratory MucosaTomography, Optical Coherence

Identifiers

PMID28819309
PMCPMC5561030
OpenAlexW2742729949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.