Evidence map›Paper›PMID 28819292›Full record

SynthesisScientific reports2017

Vitrification versus slow freezing for human ovarian tissue cryopreservation: a systematic review and meta-anlaysis.

Qingquan Shi, Yidong Xie, Yan Wang, Shangwei Li

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Trial
  6. Article
  7. Review
  8. Article
  9. Review
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  11. Review
  12. Cryopreservation of Ovarian Cortex Tissue.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  13. [Ovarian tissue cryopreservation and transplantation: a review of clinical progress in fertility preservation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
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  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qingquan ShiDepartment of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, 610000, China.
Yidong XieDepartment of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, 610000, China.
Yan WangDepartment of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, 610000, China.
Shangwei LiDepartment of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, 610000, China. lswivf@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitrification is a well-accepted procedure for cryopreservation of gametes and embryos. Less is known, however, about its performance in preserving ovarian tissue, for which slow freezing is the current convention. Increasing interest is being focused on vitrification, but there are as yet no standard protocols for its use with ovarian tissue. In part, this is because of the variety of cell types and complex nature of ovarian tissue. We performed a meta-analysis of 14 studies that compared vitrification with slow freezing for cryopreservation of ovarian tissue. In the pooled analysis, there was no significant difference between the two methods in terms of the proportion of intact primordial follicles, but vitrification was associated with significantly less DNA damage. Secondary endpoints included the number of stromal cells, significantly higher with vitrification, and primordial follicle density, which did not differ between the two methods. The present meta-analysis suggests that vitrification may be more effective than slow freezing, with less primordial follicular DNA strand breaks and better preservation of stromal cells. These advantages should lead to improved ovarian function after transplantation.

Indexed as

FreezingVitrificationCryopreservationDNA DamageFemaleHumansOvarian FollicleOvaryReproducibility of ResultsStromal Cells

Identifiers

PMID28819292
PMCPMC5561141

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.