ArticleScientific reports2017
Disruption of the plant-specific CFS1 gene impairs autophagosome turnover and triggers EDS1-dependent cell death.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Beyond parallel pathways: molecular integration and functional crosstalk between autophagy and endocytosis in plants.Protoplasma · 2026Review
- ESCRT: A Cellular Nexus of Plant Immunity and Pathogen Counter-Strategies.Molecular plant pathology · 2026Review
- Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Autophagosome biogenesis and organelle homeostasis in plant cells.The Plant cell · 2024Review
- A sword or a buffet: plant endomembrane system in viral infections.Frontiers in plant science · 2023Review
- The phosphatidylinositol 3-phosphate effector FYVE3 regulates FYVE2-dependent autophagy inFrontiers in plant science · 2023Article
- Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole.The Journal of cell biology · 2022Article
- BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass.Cell metabolism · 2022Article
- The PH Domain and C-Terminal polyD Motif of Phafin2 Exhibit a Unique Concurrence in Animals.Membranes · 2022Article
- FYVE2, a phosphatidylinositol 3-phosphate effector, interacts with the COPII machinery to control autophagosome formation in Arabidopsis.The Plant cell · 2022Article
- Molecular mechanisms of endomembrane trafficking in plants.The Plant cell · 2022Review
- An Overview of the Molecular Mechanisms and Functions of Autophagic Pathways in Plants.Plant signaling & behavior · 2021Article
- Attracted to membranes: lipid-binding domains in plants.Plant physiology · 2021Article
- Evolutionary insights into FYVE and PHOX effector proteins from the moss Physcomitrella patens.Planta · 2020Article
- Autophagy: An Intracellular Degradation Pathway Regulating Plant Survival and Stress Response.Frontiers in plant science · 2020Review
- Understanding and exploiting autophagy signaling in plants.Essays in biochemistry · 2017Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell death, autophagy and endosomal sorting contribute to many physiological, developmental and immunological processes in plants. They are mechanistically interconnected and interdependent, but the molecular basis of their mutual regulation has only begun to emerge in plants. Here, we describe the identification and molecular characterization of CELL DEATH RELATED ENDOSOMAL FYVE/SYLF PROTEIN 1 (CFS1). The CFS1 protein interacts with the ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT I (ESCRT-I) component ELCH (ELC) and is localized at ESCRT-I-positive late endosomes likely through its PI3P and actin binding SH3YL1 Ysc84/Lsb4p Lsb3p plant FYVE (SYLF) domain. Mutant alleles of cfs1 exhibit auto-immune phenotypes including spontaneous lesions that show characteristics of hypersensitive response (HR). Autoimmunity in cfs1 is dependent on ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1)-mediated effector-triggered immunity (ETI) but independent from salicylic acid. Additionally, cfs1 mutants accumulate the autophagy markers ATG8 and NBR1 independently from EDS1. We hypothesize that CFS1 acts at the intersection of autophagosomes and endosomes and contributes to cellular homeostasis by mediating autophagosome turnover.
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