ArticleScientific reports2017
Impact of sex, fat distribution and initial body weight on oxytocin's body weight regulation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 56 citations in OpenAlex.
- Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder.The International journal of eating disorders · 2026Trial
- Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels.Frontiers in endocrinology · 2024Trial
- Role of Oxytocin in Obesity.Current diabetes reports · 2026Review
- Oxytocin receptor signaling contributes to the mitochondrial integrity and maintain gastric mucosal homeostasis in male mice.iScience · 2026Article
- Gsformer: a dual-architecture deep learning framework with CNN-self-attention and sparse-attention for genomic selection.Genetics, selection, evolution : GSE · 2026Article
- The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
- Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide.Aging cell · 2025Article
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Article
- Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.Nature metabolism · 2025Article
- Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats.bioRxiv : the preprint server for biology · 2025Article
- Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats.Frontiers in endocrinology · 2025Article
- Sympathetic Innervation of Interscapular Brown Adipose Tissue Is Not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats.Current issues in molecular biology · 2024Article
- The Effects of Testosterone on Hypothalamic and Serum Oxytocin Levels Are Affected by the Estrogen Milieu in Female Rats.Nutrients · 2024Article
- Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice.Frontiers in endocrinology · 2024Article
- Article
- Novel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight.International journal of molecular sciences · 2022Article
- Oestrogen-dependent hypothalamic oxytocin expression with changes in feeding and body weight in female rats.Communications biology · 2022Article
- Oxytocin as a potential pharmacological tool to combat obesity.Journal of neuroendocrinology · 2022Review
- Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial body weight, and fat distribution) that may affect the ability of Oxt to regulate body weight (BW). With regard to sex, Oxt reduced BW similarly in males and females under both high fat diet (HFD) and standard chow-fed condition. The BW reduction induced by Oxt correlated with initial BW in male and female mice under HFD conditions. Oxt showed an equal efficacy in fat degradation in both the visceral and subcutaneous fat mass in both males and females fed with HFD. The effect of Oxt on BW reduction was attenuated in standard chow-fed male and female mice. Therefore, our results suggest that administration of Oxt is more effective in reducing BW in subjects with a high initial BW with increased fat accumulation. The present data contains important information for the possible clinical application of Oxt for the treatment of obesity.
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