ArticleScientific reports2017
Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors.Malaria journal · 2018Pooled it
- Evaluation of the safety and insecticidal efficacy of ivermectin-treated bird feed formulations in different avian species.Parasites & vectors · 2026Article
- Toxicity of ivermectin on multiple insecticide-resistant populations of Anopheles gambiae sensu lato, Aedes aegypti, and Culex mosquitoes.Parasites & vectors · 2026Article
- Evaluation of the safety and insecticidal efficacy of ivermectin-treated bird feed formulations in different avian species.bioRxiv : the preprint server for biology · 2025Article
- Experimental study on the effect of Ivermectin on cattle dung faunas in Eastern Ethiopia.PloS one · 2025Article
- Ivermectin resistance mechanisms in ectoparasites: a scoping review.Parasitology research · 2024Article
- Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s.Parasites & vectors · 2023Article
- Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes.Malaria journal · 2023Article
- Malaria vector bionomics in Taita-Taveta County, coastal Kenya.Parasites & vectors · 2022Article
- Polypharmacy Exposure, Aging Populations, and COVID-19: Considerations for Healthcare Providers and Public Health Practitioners in Africa.International journal of environmental research and public health · 2021Article
- Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects.Archives of toxicology · 2021Review
- The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes.PLoS pathogens · 2021Article
- The effect of ivermectin alone and in combination with cobicistat or elacridar in experimental Schistosoma mansoni infection in mice.Scientific reports · 2021Article
- Veterinary endectocides for malaria control and elimination: prospects and challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Study on individualized analgesia guided byAmerican journal of translational research · 2021Article
- In Silico Investigation of First-Pass Effect on Selected Small Molecule Excipients and Structural Dynamics of P-glycoprotein.Bioinformatics and biology insights · 2020Article
- The effect of ivermectinMalaria journal · 2019Article
- Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals.PLoS neglected tropical diseases · 2019Article
- Optimising systemic insecticide use to improve malaria control.BMJ global health · 2019Article
- Combined effect of the entomopathogenic fungusPeerJ · 2019Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission. Ivermectin is one of the leading candidates given its excellent safety profile. Here we provide proof that the effect of ivermectin can be boosted at two different levels by drugs inhibiting the cytochrome or ABC transporter in the mammal host and the target mosquitoes. Using a mini-pig model, we show that drug-mediated cytochrome P450/ABC transporter inhibition results in a 3-fold increase in the time ivermectin remains above mosquito-killing concentrations. In contrast, P450/ABC transporter induction with rifampicin markedly impaired ivermectin absorption. The same ketoconazole-mediated cytochrome/ABC transporter inhibition also occurs outside the mammal host and enhances the mortality of Anopheles gambiae. This was proven by using the samples from the mini-pig experiments to conduct an ex-vivo synergistic bioassay by membrane-feeding Anopheles mosquitoes. Inhibiting the same cytochrome/xenobiotic pump complex in two different organisms to simultaneously boost the pharmacokinetic and pharmacodynamic activity of a drug is a novel concept that could be applied to other systems. Although the lack of a dose-response effect in the synergistic bioassay warrants further exploration, our study may have broad implications for the control of parasitic and vector-borne diseases.
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