ArticleNature communications2017
Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Brain organoids as models of extracellular vesicle-mediated human neural communication.Neural regeneration research · 2026Article
- Design and optimization of in situ self-functionalizing stress sensors.The European physical journal. E, Soft matter · 2026Article
- Mechanical constraints on cell plasticity: insights from the olfactory epithelium.Frontiers in cell and developmental biology · 2026Review
- KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.Development (Cambridge, England) · 2025Article
- Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.iScience · 2025Article
- Mechanodynamic brain on chip for studying human stem cell derived neuronal networks.Scientific reports · 2025Article
- Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Pharmacological Activation of Piezo1 Channels Enhances Astrocyte-Neuron Communication via NMDA Receptors in the Murine Neocortex.International journal of molecular sciences · 2024Article
- Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly.Development (Cambridge, England) · 2023Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril.Developmental cell · 2023Article
- Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- C. elegans as a model to study glial development.The FEBS journal · 2022Review
- The eye tugs and the nose follows: how inter-tissue adhesion directs olfactory development.EMBO reports · 2022Article
- Article
- Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine.Cytoskeleton (Hoboken, N.J.) · 2021Review
- Establishment and Maintenance of Neural Circuit Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- How Smooth Muscle Contractions Shape the Developing Enteric Nervous System.Frontiers in cell and developmental biology · 2021Article
- Mechanobiology of neural development.Current opinion in cell biology · 2020Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To form functional neural circuits, neurons migrate to their final destination and extend axons towards their targets. Whether and how these two processes are coordinated in vivo remains elusive. We use the zebrafish olfactory placode as a system to address the underlying mechanisms. Quantitative live imaging uncovers a choreography of directed cell movements that shapes the placode neuronal cluster: convergence of cells towards the centre of the placodal domain and lateral cell movements away from the brain. Axon formation is concomitant with lateral movements and occurs through an unexpected, retrograde mode of extension, where cell bodies move away from axon tips attached to the brain surface. Convergence movements are active, whereas cell body lateral displacements are of mainly passive nature, likely triggered by compression forces from converging neighbouring cells. These findings unravel a previously unknown mechanism of neuronal circuit formation, whereby extrinsic mechanical forces drive the retrograde extension of axons.How neuronal migration and axon growth coordinate during development is only partially understood. Here the authors use quantitative imaging to characterise the morphogenesis of the zebrafish olfactory placode and report an unexpected phenomenon, whereby axons extend through the passive movement of neuron cell bodies away from tethered axon tips.
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