Evidence map›Paper›PMID 28819188›Full record

ArticleScientific reports2017

Highly Stabilized Core-Satellite Gold Nanoassemblies in Vivo: DNA-Directed Self-Assembly, PEG Modification and Cell Imaging.

Liangfeng Tang, Guiping Yu, Lishan Tan, Min Li, Xiulong Deng, Jianyu Liu, Aiqing Li, Xuandi Lai, Jianqiang Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liangfeng TangKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Guiping YuKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Lishan TanState Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Min LiKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Xiulong DengKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Jianyu LiuKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China. jyliu@scut.edu.cn.
Aiqing LiState Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. liaiqing@smu.edu.cn.
Xuandi LaiKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Jianqiang HuKey Laboratory of Fuel Cell Technology of Guangdong Province, Department of Chemistry, College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China. jqhusc@scut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Au nanoparticles (NPs) have important applications in bioimaging, clinical diagnosis and even therapy due to its water-solubility, easy modification and drug-loaded capability, however, easy aggregation of Au NPs in normal saline and serum greatly limits its applications. In this work, highly stabilized core-satellite Au nanoassemblies (CSAuNAs) were constructed by a hierarchical DNA-directed self-assembly strategy, in which satellite Au NPs number could be effectively tuned through varying the ratios of core-AuNPs-ssDNA and satellite-AuNPs-ssDNAc. It was especially interesting that PEG-functionalized CSAuNAs (PEG-CSAuNAs) could not only bear saline solution but also resist the enzymatic degradation in fetal calf serum. Moreover, cell targeting and imaging indicated that the PEG-CSAuNAs had promising biotargeting and bioimaging capability. Finally, fluorescence imaging in vivo revealed that PEG-CSAuNAs modified with N-acetylation chitosan (CSNA) could be selectively accumulate in the kidneys with satisfactory renal retention capability. Therefore, the highly stabilized PEG-CSAuNAs open a new avenue for its applications in vivo.

Indexed as

AcetylationAnimalsCell LineChitosanDNA, Single-StrandedFluorescenceGoldHumansMaleMetal NanoparticlesMice, Inbred BALB CMicroscopy, Electron, TransmissionPolyethylene GlycolsTissue DistributionChitosanDNA, Single-StrandedGoldPolyethylene Glycols

Identifiers

PMID28819188
PMCPMC5561241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.