ArticleScientific reports2017
Context conditioning in humans using commercially available immersive Virtual Reality.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Agent-Based Behavioral Modeling of Human Associative Learning in a Complex Approach-Avoidance Conflict Task.Computational brain & behavior · 2025Article
- PanicRoom: a virtual reality-based Pavlovian fear conditioning paradigm.Frontiers in psychology · 2024Article
- Altered frontolimbic activity during virtual reality-based contextual fear learning in patients with posttraumatic stress disorder.Psychological medicine · 2023Article
- Measuring human context fear conditioning and retention after consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Head-Mounted Display-Based Application for Cognitive Training.Sensors (Basel, Switzerland) · 2020Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- Generalization of Conditioned Contextual Anxiety and the Modulatory Effects of Anxiety Sensitivity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Quantifying Human Avoidance Behavior in Immersive Virtual Reality.Frontiers in behavioral neuroscience · 2020Article
- Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.Neuroscience and biobehavioral reviews · 2019Review
- Patients with dorsolateral prefrontal cortex lesions are capable of discriminatory threat learning but appear impaired in cognitive regulation of subjective fear.Social cognitive and affective neuroscience · 2019Article
- From Extinction Learning to Anxiety Treatment: Mind the Gap.Brain sciences · 2019Article
- [Development of virtual reality as an exposure technique].Der Nervenarzt · 2019Review
- The emotional brain: Fundamental questions and strategies for future research.Neuroscience letters · 2019Article
- The emerging neuroscience of appetitive and drug cue extinction in humans.Psychopharmacology · 2019Review
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
- Article
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Authors and funding
5 authors.
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Abstract
Despite a wealth of knowledge on how humans and nonhuman animals learn to associate meaningful events with cues in the environment, far less is known about how humans learn to associate these events with the environment itself. Progress on understanding spatiotemporal contextual processes in humans has been slow in large measure by the methodological constraint of generating and manipulating immersive spatial environments in well-controlled laboratory settings. Fortunately, immersive Virtual Reality (iVR) technology has improved appreciably and affords a relatively straightforward methodology to investigate the role of context on learning, memory, and emotion while maintaining experimental control. Here, we review context conditioning literature in humans and describe challenges to study contextual learning in humans. We then provide details for a novel context threat (fear) conditioning paradigm in humans using a commercially available VR headset and a cross-platform game engine. This paradigm resulted in the acquisition of subjective threat, threat-conditioned defensive responses, and explicit threat memory. We make the paradigm publicly available and describe obstacles and solutions to optimize future studies of context conditioning using iVR. As computer technology advances to replicate the sensation of realistic environments, there are increasing opportunities to bridge the translational gap between rodent and human research on how context modulates cognition, which may ultimately lead to more optimal treatment strategies for anxiety- and stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.