ArticleScientific reports2017
Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
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- Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- A Review of the Pharmacological Potential ofCells · 2022Review
- Flavonoids as Potential Antiviral Agents for Porcine Viruses.Pharmaceutics · 2022Review
- Effects of Quercitrin on PRV-Induced Secretion of Reactive Oxygen Species and Prediction of lncRNA Regulatory Targets in 3D4/2 Cells.Antioxidants (Basel, Switzerland) · 2022Article
- Maackiain Modulates miR-374a/GADD45A Axis to Inhibit Triple-Negative Breast Cancer Initiation and Progression.Frontiers in pharmacology · 2022Article
- Enhancement of intestinal mucosal immunity and immune response to the foot-and-mouth disease vaccine by oral administration of danggui buxue decoction.Frontiers in veterinary science · 2022Article
- Microwave-Assisted Enzymatic Extraction of Flavonoids fromMolecules (Basel, Switzerland) · 2021Article
- Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production.Frontiers in immunology · 2021Review
- The Antitriple Negative Breast cancer Efficacy ofOxidative medicine and cellular longevity · 2021Article
- Immunostimulatory Effects of Polysaccharides fromMarine drugs · 2020Article
- Haemato-biochemical alterations and oxidative stress associated with naturally occurring porcine circovirus2 infection in pigs.Tropical animal health and production · 2020Article
- Synthesis of caffeic acid sulfonamide derivatives and their protective effect against HRSC advances · 2020Article
- Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis.Frontiers in pharmacology · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice induced by porcine circovirus type 2 (PCV2) infection. The PCV2 infection leads to significant decrease in thymus and spleen indices, elevation of xanthine oxidase (XOD) and myeloperoxidase (MPO) activities, reduction in GSH level and GSH to GSSG ratio and decline of superoxide dismutase (SOD) activity, indicating the formation of immunosuppression and oxidative stress. TFSD treatment recovered the alteration of viscera index, antioxidant content and activities of oxidative-associated enzymes to a level similar to control. Our findings suggested that PCV2 induced immunosuppression and oxidative stress in mice and TFSD might be able to protect animals from virus infection via regulation of immune function and inhibition of oxidative stress.
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