ArticleScientific reports2017
The possible molecular mechanisms of bisphenol A action on porcine early embryonic development.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Protective Effect of Melatonin Against Bisphenol A Toxicity.International journal of molecular sciences · 2025Review
- Salidroside Reduced CaCell biochemistry and biophysics · 2024Article
- Bisphenol A (BPA) toxicity assessment and insights into current remediation strategies.RSC advances · 2024Review
- Impact of Microplastics on the Ocular Surface.International journal of molecular sciences · 2023Review
- Article
- Bisphenol Exposure Disrupts Cytoskeletal Organization and Development of Pre-Implantation Embryos.Cells · 2022Article
- 3,4‑Dihydroxyacetophenone attenuates oxidative stress‑induced damage to HUVECs via regulation of the Nrf2/HO‑1 pathway.Molecular medicine reports · 2022Article
- Astaxanthin improves the development of the follicles and oocytes through alleviating oxidative stress induced by BPA in cultured follicles.Scientific reports · 2022Article
- Article
- BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development.Reproductive biology and endocrinology : RB&E · 2021Article
- Pistacia integerrima alleviated Bisphenol A induced toxicity through Ubc13/p53 signalling.Molecular biology reports · 2020Article
- Effect of Triclosan Exposure on Developmental Competence in Parthenogenetic Porcine Embryo during Preimplantation.International journal of molecular sciences · 2020Article
- Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction.Antioxidants (Basel, Switzerland) · 2020Review
- Bisphenol S Impaired In Vitro Ovine Early Developmental Oocyte Competence.International journal of molecular sciences · 2020Article
- Hydrogen Peroxide Production by the Spot-Like Mode Action of Bisphenol A.Frontiers in plant science · 2020Article
- Environmental Pollution as a Risk Factor in Testicular Tumour Development: Focus on the Interaction between Bisphenol A and the Associated Immune Response.International journal of environmental research and public health · 2019Article
- Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis.Chemical research in toxicology · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA) is an environmental contaminant widely used in the plastic industry. BPA has been demonstrated to be an endocrine disruptor and has an adverse effect on the embryonic development of mammals. However, the mechanism of action of BPA is limited. In this study, we investigated the role and mechanism of BPA in porcine embryonic development. First, the parthenotes were treated with different concentrations of BPA. We found that blastocyst formation was impaired and the parthenotes were arrested at the 4-cell stage after treatment with 100 μm BPA. Second, ROS increased following the addition of BPA, which further caused mitochondrial damage, and cytochrome c was released from the mitochondria to induce apoptosis. The adaptive response was demonstrated through LC3 immunofluorescence staining and by assessing autophagy-related gene expression. In addition, BPA caused DNA damage through the p53-p21 signaling pathway. Thus, our results indicate that BPA displays an adverse effect on porcine early embryonic development through mitochondrial and DNA damage.
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