ArticleScientific reports2017
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.Malaria journal · 2023Trial
- Innate immune responses to pathogens at the maternal-fetal interface.Nature reviews. Immunology · 2025Review
- Asprosin activates multiple placental pathwaysMolecular medicine reports · 2025Article
- Maternal undernourishment impairs murine placental development during pregnancy.BMC pregnancy and childbirth · 2025Article
- Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Natural hemozoin and β-hematin induce tissue damage and apoptosis in human placental explants.Toxicology reports · 2025Article
- Modulation of the Toll-like Receptor Pathway in Ovine Endometria During Early Pregnancy.Animals : an open access journal from MDPI · 2025Article
- Role of inflammasomes in Toxoplasma and Plasmodium infections.Parasites & vectors · 2024Review
- Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation.Nature communications · 2024Article
- Aberrant CD8Frontiers in immunology · 2024Article
- Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders.Neuronal signaling · 2023Review
- Potential pharmacologic interventions targeting TLR signaling in placental malaria.Trends in parasitology · 2022Review
- Homeostasis Maintenance inFrontiers in immunology · 2022Article
- Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice.Scientific reports · 2021Article
- TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria.Infection and immunity · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
- Early pregnancy affects expression of Toll-like receptor signaling members in ovine spleen.Animal reproduction · 2021Article
- Asiaticoside attenuates neonatal hypoxic-ischemic brain damage through inhibiting TLR4/NF-κB/STAT3 pathway.Annals of translational medicine · 2020Article
- Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes.Science advances · 2020Article
- Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface.Frontiers in immunology · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The detrimental effects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the effect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.