Evidence map›Paper›PMID 28818973›Full record

ArticleScience (New York, N.Y.)2017

Mutations in the promoter of the telomerase gene

Kunitoshi Chiba, Franziska K Lorbeer, A Hunter Shain, David T McSwiggen, Eva Schruf, Areum Oh, Jekwan Ryu, Xavier Darzacq, Boris C Bastian, Dirk Hockemeyer

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 4 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 4 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. How telomere attrition protects against cancer.Nature reviews. Genetics · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Clonal Signatures of Telomere Biology Disorders.Current hematologic malignancy reports · 2026
    Review
  11. Biogenesis and Regulation of Telomerase during Development and Cancer.Cold Spring Harbor perspectives in biology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kunitoshi ChibaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-3385-9308
Franziska K LorbeerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3152-6852
A Hunter ShainDepartments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.ORCID 0000-0002-2999-9706
David T McSwiggenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-3844-7433
Eva SchrufDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Areum OhOptical Biosystems, Santa Clara, CA 95050, USA.ORCID 0000-0001-6386-1391
Jekwan RyuOptical Biosystems, Santa Clara, CA 95050, USA.ORCID 0000-0002-4447-7017
Xavier DarzacqDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2537-8395
Boris C BastianDepartments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.ORCID 0000-0003-1836-6062
Dirk HockemeyerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. hockemeyer@berkeley.edu.ORCID 0000-0002-5598-5092
University of California, Berkeley · USOracle (United States) · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Molecular and immunologic evolution of melanomas from pre-neoplastic lesionsR35CA220481 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C. · 2017 to 2023
$6.3M
The GNAQ pathway as a therapeutic target in uveal melanomaR01CA142873 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C. · 2010 to 2017
$2.2M
Telomerase function in human tumor and stem cell biologyR01CA196884 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOCKEMEYER, DIRK · 2015 to 2019
$1.7M
Molecular Pathology of CancerT32CA177555 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C., OAKES, SCOTT A. · 2013 to 2017
$1.1M
NCI NIH HHS R01 CA142873NCI NIH HHS R01 CA196884NCI NIH HHS R35 CA220481NCI NIH HHS T32 CA177555
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CarcinogenesisCells, CulturedGenomic InstabilityHumansMelanomaMutationPromoter Regions, GeneticSkin NeoplasmsTelomeraseTelomereTelomere ShorteningTelomeraseTERT protein, human

Identifiers

PMID28818973
PMCPMC5942222
OpenAlexW2749114826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.