ArticleScience (New York, N.Y.)2017
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 93 citations in OpenAlex.
- Conserved sex-biased DNA methylation patterns target key developmental genes and reproductive function in two Poeciliidae species.G3 (Bethesda, Md.) · 2026Article
- The persisting presence of absence in female sex development: a critical interdisciplinary reflection.Biology of sex differences · 2026Review
- Crucial roles of mesenchymalProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive system†.Biology of reproduction · 2025Article
- Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.Science translational medicine · 2025Article
- Genetics and Pathophysiology of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.The Journal of clinical endocrinology and metabolism · 2025Review
- Tissue clearing and imaging approaches for in toto analysis of the reproductive system†.Biology of reproduction · 2024Review
- Conserved genes regulating human sex differentiation, gametogenesis and fertilization.Journal of translational medicine · 2024Review
- COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors.Cell & bioscience · 2024Article
- Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development.Endocrinology · 2023Article
- Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delays.European journal of human genetics : EJHG · 2023Article
- Epithelial and mesenchymal fate decisions in Wolffian duct development.Trends in endocrinology and metabolism: TEM · 2023Review
- Genetic control of typical and atypical sex development.Nature reviews. Urology · 2023Review
- An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.Nature communications · 2023Article
- Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on Amhr2+ mesenchyme in mice†.Biology of reproduction · 2022Article
- A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.Cellular and molecular life sciences : CMLS · 2022Article
- Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract.PNAS nexus · 2022Article
- COUP-TFII in Kidneys, from Embryos to Sick Adults.Diagnostics (Basel, Switzerland) · 2022Review
- Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.Journal of anatomy · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.