Evidence map›Paper›PMID 28818869›Full record

ArticleHaematologica2017

Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases.

Staci D Arnold, Ruta Brazauskas, Naya He, Yimei Li, Richard Aplenc, Zhezhen Jin, Matt Hall, Yoshiko Atsuta, Jignesh Dalal, Theresa Hahn and 35 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Article
  9. The effectiveness of hematopoietic stem cell transplantation in treating pediatric sickle cell disease: Systematic review and meta-analysis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  10. A landscape analysis and discussion of value of gene therapies for sickle cell disease.Expert review of pharmacoeconomics & outcomes research · 2022
    Article
  11. Article
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  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 20 institutions in 8 countries.

Staci D ArnoldEmory University Hospital, Atlanta, GA, USA.
Ruta BrazauskasCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Naya HeCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Yimei LiUniversity of Pennsylvania, Philadelphia, PA, USA.
Richard AplencUniversity of Pennsylvania, Philadelphia, PA, USA.
Zhezhen JinDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Matt HallDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
Jignesh DalalRainbow Babies & Children's Hospital, Cleveland, OH, USA.
Theresa HahnDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Nandita KheraDepartment of Hematology/Oncology, Mayo Clinic, Phoenix, AZ, USA.
Carmem BonfimHospital de Clinicas-Federal University of Parana, Curitiba, Brazil.
Navneet S MajhailBlood & Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Miguel Angel DiazDepartment of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
Cesar O FreytesTexas Transplant Institute, San Antonio, TX, USA.
William A WoodDivision of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Rammurti T KambleDivsion of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Susan ParsonsTufts Medical Center, Boston, MA, USA.
Ibrahim AhmedRainbow Babies & Children's Hospital, Cleveland, OH, USA.
Keith SullivanDuke University Medical Center, Durham, NC, USA.
Sara BeattieUniversity of Ottawa, Canada.
Christopher DandoyCincinnati Children's Hospital Medical Center, OH, USA.
Reinhold MunkerSection of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA, USA.
Susana MarinoUniversity of Chicago Hospitals, Chicago, IL, USA.
Menachem BitanDepartment of Pediatric Hematology/Oncology, Tel-Aviv Sourasky Medical Center, Israel.
Hisham Abdel-AzimDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, CA, USA.
Mahmoud AljurfDepartment of Oncology, King Faisal Specialist Hospital Center & Research, Riydah, Saudi Arabia.
Richard F OlssonDivision of Therapeutic Immunology, Department of Laboratory Medicine, Karolinksa Institutet, Stockholm, Sweden.
Sarita JoshiPediatric Hematology, Oncology and BMT, Nationwide Children's Hospital and Ohio State University Wexner, Columbus, OH, USA.
Dave BuchbinderDivision of Pediatrics Hematology, Children's Hospital of Orange County, Orange, CA, USA.
Michael J EckrichLevine Children's Hospital, Charlotte, NC, USA.
Shahrukh HashmiDepartment of Oncology, King Faisal Specialist Hospital Center & Research, Riydah, Saudi Arabia.
Hillard LazarusSeidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA.
David I MarksAdult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.
Amir SteinbergDepartment of Hematology-Oncology, Mount Saini Hospital, New York, NY, USA.
Ayman SaadDivision of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Usama GergisHematologic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY, USA.
Lakshmanan KrishnamurtiEmory University Hospital, Atlanta, GA, USA.
Allistair AbrahamDivision of Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA.
Hemalatha G RangarajanPediatric Hematology, Oncology and BMT, Nationwide Children's Hospital and Ohio State University Wexner, Columbus, OH, USA.
Mark WaltersChildren's Hospital & Research Center Oakland, Oakland, NY, USA.
Joseph LipscombHealth Policy and Management, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Wael SaberCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA wsaber@mcw.edu.
Prakash SatwaniDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.
Medical College of Wisconsin · USColumbia University Irving Medical Center · USEmory University Hospital · USNationwide Children's Hospital · USRainbow Babies & Children's Hospital · USUniversity of Pennsylvania · USBaylor College of Medicine · USChildren's Hospital of Orange County · USChildren's National · USCHRISTUS Transplant Institute · USCincinnati Children's Hospital Medical Center · USCleveland Clinic · USColumbia University · USDuke Medical Center · USEmory University · USHospital Infantil Universitario Niño Jesús · ESKing Faisal Specialist Hospital & Research Centre · SALevine Children's Hospital · USLouisiana State University · USMayo Clinic in Arizona · US

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Advances in allogeneic hematopoietic cell transplantation for sickle cell disease have improved outcomes, but there is limited analysis of healthcare utilization in this setting. We hypothesized that, compared to late transplantation, early transplantation (at age <10 years) improves outcomes

Indexed as

Hematopoietic Stem Cell TransplantationPatient Acceptance of Health CareAdolescentAnemia, Sickle CellBone Marrow TransplantationChildChild, PreschoolClinical Decision-MakingComorbidityDatabases, FactualFemaleGraft vs Host DiseaseHealth Care CostsHumansIncidenceInfant

Identifiers

PMID28818869
PMCPMC5664386
OpenAlexW2745596189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.