ArticleBiology open2017
HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner.
Article in Biology open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis.Communications biology · 2026Article
- Shared Disease Mechanisms in Neurodevelopmental Disorders: A Cellular and Molecular Biology Perspective.Brain sciences · 2025Review
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- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine.Patterns (New York, N.Y.) · 2023Review
- Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissues.iScience · 2023Review
- Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR.Nature communications · 2022Article
- A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.Scientific reports · 2022Article
- Cytochalasin B Modulates Nanomechanical Patterning and Fate in Human Adipose-Derived Stem Cells.Cells · 2022Article
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Two HCN4 Channels Play Functional Roles in the Zebrafish Heart.Frontiers in physiology · 2022Article
- Unveiling the morphogenetic code: A new path at the intersection of physical energies and chemical signaling.World journal of stem cells · 2021Review
- A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies.Scientific reports · 2021Article
- Editorial: Interplay Between Ion Channels, the Nervous System, and Embryonic Development.Frontiers in molecular neuroscience · 2021Article
- The genetic factors of bilaterian evolution.eLife · 2020Article
- HCN2 Channel-Induced Rescue of Brain TeratogenesisFrontiers in cellular neuroscience · 2020Article
- Review
- Modeling somatic computation with non-neural bioelectric networks.Scientific reports · 2019Article
- Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laterality is a basic characteristic of all life forms, from single cell organisms to complex plants and animals. For many metazoans, consistent left-right asymmetric patterning is essential for the correct anatomy of internal organs, such as the heart, gut, and brain; disruption of left-right asymmetry patterning leads to an important class of birth defects in human patients. Laterality functions across multiple scales, where early embryonic, subcellular and chiral cytoskeletal events are coupled with asymmetric amplification mechanisms and gene regulatory networks leading to asymmetric physical forces that ultimately result in distinct left and right anatomical organ patterning. Recent studies have suggested the existence of multiple parallel pathways regulating organ asymmetry. Here, we show that an isoform of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of ion channels (hyperpolarization-activated cyclic nucleotide-gated channel 4, HCN4) is important for correct left-right patterning. HCN4 channels are present very early in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.