ArticleNeuroImage2018
Diffusion time dependence of microstructural parameters in fixed spinal cord.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- The diagnostic and prediction performance of MR diffusion kurtosis imaging in the glioma molecular classification: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Myo-inositol concentration in the medial prefrontal cortex is associated with changes in brain white matter microstructure in early psychosis.Translational psychiatry · 2026Article
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Quantitative MRI in Neuroimaging: A Review of Techniques, Biomarkers, and Emerging Clinical Applications.Brain sciences · 2025Review
- White matter microstructure alterations in early psychosis and schizophrenia.Translational psychiatry · 2025Article
- Comparison of different neurite density metrics with brain asymmetry evaluation.Zeitschrift fur medizinische Physik · 2025Article
- Romer-EPTI: Rotating-view motion-robust super-resolution EPTI for SNR-efficient distortion-free in-vivo mesoscale diffusion MRI and microstructure imaging.Magnetic resonance in medicine · 2025Article
- Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue.NMR in biomedicine · 2025Article
- QSI and DTI of Inherited White Matter Disorders in Rat Spinal Cord: Early Detection and Comparison with Quantitative Electron Microscopy Findings.Diagnostics (Basel, Switzerland) · 2025Article
- Denoising Improves Cross-Scanner and Cross-Protocol Test-Retest Reproducibility of Diffusion Tensor and Kurtosis Imaging.Human brain mapping · 2025Article
- Revealing membrane integrity and cell size from diffusion kurtosis time dependence.Magnetic resonance in medicine · 2025Article
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- Romer-EPTI: rotating-view motion-robust super-resolution EPTI for SNR-efficient distortion-free in-vivo mesoscale dMRI and microstructure imaging.bioRxiv : the preprint server for biology · 2024Article
- The effects of axonal beading and undulation on axonal diameter estimation from diffusion MRI: Insights from simulations in human axons segmented from three-dimensional electron microscopy.NMR in biomedicine · 2024Article
- Insights and improvements in correspondence between axonal volume fraction measured with diffusion-weighted MRI and electron microscopy.NMR in biomedicine · 2024Article
- Volume electron microscopy in injured rat brain validates white matter microstructure metrics from diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Multi-tensor fixel-based metrics in tractometry: application to multiple sclerosis.Frontiers in neuroscience · 2024Article
- ACID: A comprehensive toolbox for image processing and modeling of brain, spinal cord, and ex vivo diffusion MRI data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Biophysical modelling of diffusion MRI is necessary to provide specific microstructural tissue properties. However, estimating model parameters from data with limited diffusion gradient strength, such as clinical scanners, has proven unreliable due to a shallow optimization landscape. On the other hand, estimation of diffusion kurtosis (DKI) parameters is more robust, and its parameters may be connected to microstructural parameters, given an appropriate biophysical model. However, it was previously shown that this procedure still does not provide sufficient information to uniquely determine all model parameters. In particular, a parameter degeneracy related to the relative magnitude of intra-axonal and extra-axonal diffusivities remains. Here we develop a model of diffusion in white matter including axonal dispersion and demonstrate stable estimation of all model parameters from DKI in fixed pig spinal cord. By employing the recently developed fast axisymmetric DKI, we use stimulated echo acquisition mode to collect data over a two orders of magnitude diffusion time range with very narrow diffusion gradient pulses, enabling finely resolved measurements of diffusion time dependence of both net diffusion and kurtosis metrics, as well as model intra- and extra-axonal diffusivities, and axonal dispersion. Our results demonstrate substantial time dependence of all parameters except volume fractions, and the additional time dimension provides support for intra-axonal diffusivity to be larger than extra-axonal diffusivity in spinal cord white matter, although not unambiguously. We compare our findings for the time-dependent compartmental diffusivities to predictions from effective medium theory with reasonable agreement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.