ArticleNeuroscience2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Transcriptomics Implicates the G3BP1-SG Axis in Cochlear Hair-Cell Pyroptosis During Age-Related Hearing Loss.Journal of cellular and molecular medicine · 2026Article
- Sestrin2 alleviates age-related hearing loss through mediating PINK1/Parkin related mitophagy.Nagoya journal of medical science · 2026Article
- Targeting Autophagy for Otoprotection: Translating Basic Mechanisms into Clinical Strategies.International journal of molecular sciences · 2026Review
- Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases.Cell death & disease · 2023Review
- Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy.Antioxidants & redox signaling · 2023Article
- Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss.Frontiers in neuroscience · 2023Review
- Possible roles of sestrin2 in multiple sclerosis and its relationships with clinical outcomes.Arquivos de neuro-psiquiatria · 2022Article
- mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss.International journal of molecular sciences · 2021Review
- The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury.Frontiers in cell and developmental biology · 2021Review
- Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function.Oxidative medicine and cellular longevity · 2021Review
- Inflammation associated with noise-induced hearing loss.The Journal of the Acoustical Society of America · 2019Review
- Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative Stress and Beyond.Journal of clinical medicine · 2019Review
- Discovery of NV-5138, the first selective Brain mTORC1 activator.Scientific reports · 2019Article
- mTOR as a central regulator of lifespan and aging.F1000Research · 2019Review
- Lower level noise exposure that produces only TTS modulates the immune homeostasis of cochlear macrophages.Journal of neuroimmunology · 2018Article
- Differential fates of tissue macrophages in the cochlea during postnatal development.Hearing research · 2018Article
- Immune cells and non-immune cells with immune function in mammalian cochleae.Hearing research · 2018Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Sestrin 2 (SESN2) is a stress-inducible protein that protects tissues from oxidative stress and delays the aging process. However, its role in maintaining the functional and structural integrity of the cochlea is largely unknown. Here, we report the expression of SESN2 protein in the sensory epithelium, particularly in hair cells. Using C57BL/6J mice, a mouse model of age-related cochlear degeneration, we observed a significant age-related reduction in SESN2 expression in cochlear tissues that was associated with early onset hearing loss and accelerated age-related sensory cell degeneration that progressed from the base toward the apex of the cochlea. Hair cell death occurred by caspase-8 mediated apoptosis. Compared to C57BL/6J control mice, Sesn2 KO mice displayed enhanced expression of proinflammatory genes and activation of basilar membrane macrophages, suggesting that loss of SESN2 function provokes the immune response. Together, these results suggest that Sesn2 plays an important role in cochlear homeostasis and immune responses to stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.