Evidence map›Paper›PMID 28818442›Full record

ArticleBrachytherapy

MRI-based treatment planning and dose delivery verification for intraocular melanoma brachytherapy.

Jacqueline Esthappan Zoberi, Jose Garcia-Ramirez, Samantha Hedrick, Vivian Rodriguez, Carol G Bertelsman, Stacie Mackey, Yanle Hu, H Michael Gach, P Kumar Rao, Perry W Grigsby

Abstract read
In one paragraph

Article in Brachytherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
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  10. Article
  11. Innovations in brachytherapy.Taiwan journal of ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacqueline Esthappan ZoberiDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO. Electronic address: jzoberi@radonc.wustl.edu.
Jose Garcia-RamirezDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO.
Samantha HedrickProvision Center for Proton Therapy, Knoxville, TN.
Vivian RodriguezDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO.
Carol G BertelsmanDepartment of Radiation Oncology, Barnes Jewish Hospital, Saint Louis, MO.
Stacie MackeyDepartment of Radiation Oncology, Barnes Jewish Hospital, Saint Louis, MO.
Yanle HuDepartment of Radiation Oncology, Mayo Clinic, Scottsdale, AZ.
H Michael GachDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO; Department of Radiology, Washington University School of Medicine, Saint Louis, MO.
P Kumar RaoDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO.
Perry W GrigsbyDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

purposeEpiscleral plaque brachytherapy (EPB) planning is conventionally based on approximations of the implant geometry with no volumetric imaging following plaque implantation. We have developed an MRI-based technique for EPB treatment planning and dose delivery verification based on the actual patient-specific geometry. METHODS AND MATERIALS: MR images of 6 patients, prescribed 85 Gy over 96 hours from Collaborative Ocular Melanoma Study-based EPB, were acquired before and after implantation. Preimplant and postimplant scans were used to generate "preplans" and "postplans", respectively. In the preplans, a digital plaque model was positioned relative to the tumor, sclera, and nerve. In the postplans, the same plaque model was positioned based on the imaged plaque. Plaque position, point doses, percentage of tumor volume receiving 85 Gy (V

resultsShifts and tilts of the plaque ranged from 1.4 to 8.6 mm and 1.0 to 3.8 mm, respectively. V

conclusionsBy implementing MRI for EPB, we eliminate reliance on approximations of the eye and tumor shape and the assumption of idealized plaque placement. With MRI, one can perform preimplant as well as postimplant imaging, facilitating EPB treatment planning based on the actual patient-specific geometry and dose-delivery verification based on the imaged plaque position.

Indexed as

Magnetic Resonance ImagingBrachytherapyHumansIodine RadioisotopesMelanomaRadiotherapy DosageRadiotherapy Planning, Computer-AssistedScleraUveal MelanomaUveal NeoplasmsIodine RadioisotopesBrachytherapyDosimetryMagnetic resonance imagingMelanomaOcular

Identifiers

PMID28818442
PMCPMC6366337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.