ArticleBMC genomics2017
Role of the type VI secretion systems during disease interactions of Erwinia amylovora with its plant host.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 39 citations in OpenAlex.
- TheMicroorganisms · 2026Article
- Evolutionary interplay: virulence, endolysin-like hydrolases, and defense correlations in the Erwinia amylovora pangenome.BMC microbiology · 2026Article
- Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales.Molecular plant pathology · 2026Review
- Article
- Review
- T6SS in plant pathogens: unique mechanisms in complex hosts.Infection and immunity · 2024Review
- Transcriptome profiling of type VI secretion system core geneMicrobiology spectrum · 2024Article
- Roles of Hcp2, a Hallmark of T6SS2 in Motility, Adhesive Capacity, and Pathogenicity ofMicroorganisms · 2023Article
- CRISPR/Cas9 mediated genome editing tools and their possible role in disease resistance mechanism.Molecular biology reports · 2022Review
- Comparative genomics to examine the endophytic potential of Pantoea agglomerans DAPP-PG 734.BMC genomics · 2022Article
- Putative transcription antiterminator RfaH contributes to Erwinia amylovora virulence.Molecular plant pathology · 2022Article
- Development of a Bacteriophage Cocktail against Pectobacterium carotovorum Subsp.Applied and environmental microbiology · 2022Article
- Genomic Characterization Provides an Insight into the Pathogenicity of the Poplar Canker BacteriumGenes · 2021Article
- Engineering disease resistant plants through CRISPR-Cas9 technology.GM crops & food · 2021Review
- Transcriptome of Pectobacterium carotovorum subsp. carotovorum PccS1 infected in calla plants in vivo highlights a spatiotemporal expression pattern of genes related to virulence, adaptation, and host response.Molecular plant pathology · 2020Article
- An Erwinia amylovora yjeK mutant exhibits reduced virulence, increased chemical sensitivity and numerous environmentally dependent proteomic alterations.Molecular plant pathology · 2018Article
- Genome-wide identification of the Sec-dependent secretory protease genes in Erwinia amylovora and analysis of their expression during infection of immature pear fruit.Journal of Zhejiang University. Science. BArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType VI secretion systems (T6SS) are widespread among Gram-negative bacteria and have a potential role as essential virulence factors or to maintain symbiotic interactions. Three T6SS gene clusters were identified in the genome of E. amylovora CFBP 1430, of which T6SS-1 and T6SS-3 represent complete T6SS machineries, while T6SS-2 is reduced in its gene content.
resultsTo assess the contribution of T6SSs to virulence and potential transcriptomic changes of E. amylovora CFBP 1430, single and double mutants in two structural genes were generated for T6SS-1 and T6SS-3. Plant assays showed that mutants in T6SS-3 were slightly more virulent in apple shoots while inducing less disease symptoms on apple flowers, indicating that T6SSs have only a minor effect on virulence of E. amylovora CFBP 1430. The mutations led under in vitro conditions to the differential expression of type III secretion systems, iron acquisition, chemotaxis, flagellar, and fimbrial genes. Comparison of the in planta and in vitro transcriptome data sets revealed a common differential expression of three processes and a set of chemotaxis and motility genes. Additional experiments proved that T6SS mutants are impaired in their motility.
conclusionThese results suggest that the deletion of T6SSs alters metabolic and motility processes. Nevertheless, the difference in lesion development in apple shoots and flower necrosis of T6SS mutants was indicative that T6SSs influences the disease progression and the establishment of the pathogen on host plants.
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