ArticleNeuron2017
Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 152 citations in OpenAlex.
- Article
- Targeting notch signaling to restore neural development and behavior in mouse models of ASD.Nature communications · 2026Article
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- Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.bioRxiv : the preprint server for biology · 2026Article
- Uncovering the molecular logic of cortical wiring between neuronal subtypes across development through ligand-receptor inference.Nature communications · 2026Article
- Developmental and early-life stress-induced effects on 5-HTNeurobiology of stress · 2026Article
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- Delayed integration of somatostatin interneurons into visual circuits.Nature communications · 2025Article
- Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome.medRxiv : the preprint server for health sciences · 2025Article
- Developmental and Early-Life Stress-Induced Effects on 5-HTbioRxiv : the preprint server for biology · 2025Article
- Ebbinghaus Illusion Distortions in Amblyopia: Impairments of Visual Size Processing and Interocular Integration.Investigative ophthalmology & visual science · 2025Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders.Biological psychiatry global open science · 2025Article
- Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain.bioRxiv : the preprint server for biology · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- Postnatal development of vasoactive intestinal polypeptide-expressing GABAergic interneurons in mouse somatosensory cortex.Acta physiologica (Oxford, England) · 2025Article
- Defects of Cortical Microcircuits Following Early Exposure to Alcohol.Advances in experimental medicine and biology · 2025Review
- Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.Brain, behavior, and immunity · 2025Article
- Stimulus-specific enhancement in mouse visual cortex requires GABA but not VIP-peptide release from VIP interneurons.Journal of neurophysiology · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to sensory stimuli and impaired sensory learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. VIDEO ABSTRACT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.