ArticlePloS one2017
From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Comparative Analysis of Leukocyte Proportions and Morphology in Wild Muridae and Arvicolinae Rodents.Biology · 2026Article
- Paying Upfront: Successful Initial Infections Protect Against Severe Future Infections.Integrative organismal biology (Oxford, England) · 2026Article
- T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep.Discovery immunology · 2025Article
- The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context.PLoS pathogens · 2024Article
- Role of bank vole (Myodes glareolus) personality on tick burden (Ixodes spp.).Folia parasitologica · 2022Article
- Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal.Scientific reports · 2022Article
- Immune stability predicts tuberculosis infection risk in a wild mammal.Proceedings. Biological sciences · 2019Article
- Immune state is associated with natural dietary variation in wild miceFunctional ecology · 2019Article
- Diet in the Driving Seat: Natural Diet-Immunity-Microbiome Interactions in Wild Fish.Frontiers in immunology · 2019Article
- Trade-off between tolerance and resistance to infections: an experimental approach with malaria parasites in a passerine bird.Oecologia · 2018Article
- The ecology of immune state in a wild mammal, Mus musculus domesticus.PLoS biology · 2018Article
- The Immunology of Wild Rodents: Current Status and Future Prospects.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek evidence of consistent difference in immunological profile amongst individuals in the wild. We apply a novel method in this context, using longitudinal (repeated capture) data from natural populations of field voles, Microtus agrestis, on a range of life history and infection metrics, and on gene expression levels. We focus on three immune genes, IFN-γ, Gata3, and IL-10, representing respectively the Th1, Th2 and regulatory elements of the immune response. Our results show that there was clear evidence of consistent differences between individuals in their typical level of expression of at least one immune gene, and at most all three immune genes, after other measured sources of variation had been taken into account. Furthermore, individuals that responded to changing circumstances by increasing expression levels of Gata3 had a correlated increase in expression levels of IFN-γ. Our work stresses the importance of acknowledging immunological variation amongst individuals in studies of parasitological and infectious disease risk in wildlife populations.
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