ArticlePLoS pathogens2017
T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
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- Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8Frontiers in immunology · 2025Article
- Fighting the enemy within: Systemic immune defense against mucosal Salmonella infection.Immunology letters · 2024Review
- Unveiling the immune dynamics ofInfection and immunity · 2024Article
- The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.Vaccine · 2023Review
- Vaccine-induced inflammation and inflammatory monocytes promote CD4+ T cell-dependent immunity against murine salmonellosis.PLoS pathogens · 2023Article
- Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppressionFrontiers in immunology · 2023Article
- Cohousing with Dirty Mice Increases the Frequency of Memory T Cells and Has Variable Effects on Intracellular Bacterial Infection.ImmunoHorizons · 2022Article
- Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice.PLoS pathogens · 2022Article
- Article
- Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information.Current opinion in immunology · 2021Review
- CD4+ T cell immunity to Salmonella is transient in the circulation.PLoS pathogens · 2021Article
- MyD88-Dependent Glucose Restriction and Itaconate Production Control Brucella Infection.Infection and immunity · 2021Article
- Inflammasomes and adaptive immune responses.Nature immunology · 2021Review
- Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection.Mucosal immunology · 2020Article
- The Role of ST2 Receptor in the Regulation ofPathogens (Basel, Switzerland) · 2020Article
- Vaccination and Infection of Swine WithFrontiers in immunology · 2020Article
- Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice.Infection and immunity · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Th1 cells can be activated by TCR-independent stimuli, but the importance of this pathway in vivo and the precise mechanisms involved require further investigation. Here, we used a simple model of non-cognate Th1 cell stimulation in Salmonella-infected mice to examine these issues. CD4 Th1 cell expression of both IL-18R and DR3 was required for optimal IFN-γ induction in response to non-cognate stimulation, while IL-15R expression was dispensable. Interestingly, effector Th1 cells generated by immunization rather than live infection had lower non-cognate activity despite comparable IL-18R and DR3 expression. Mice lacking T cell intrinsic expression of MyD88, an important adapter molecule in non-cognate T cell stimulation, exhibited higher bacterial burdens upon infection with Salmonella, Chlamydia or Brucella, suggesting that non-cognate Th1 stimulation is a critical element of efficient bacterial clearance. Thus, IL-18R and DR3 are critical players in non-cognate stimulation of Th1 cells and this response plays an important role in protection against intracellular bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.