ArticlePloS one2017
Clinical signs, profound acidemia, hypoglycemia, and hypernatremia are predictive of mortality in 1,400 critically ill neonatal calves with diarrhea.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 83 citations in OpenAlex.
- Effects on health and antioxidant status of oral supplementation of hazelnut skin extract in dairy calves with neonatal diarrhea: a randomized clinical trial in hospitalized patients.The veterinary quarterly · 2026Article
- Gastroschisis-Like Defect in a Crossbred Bovine Calf: Anatomical, Clinical and Surgical Perspectives.Veterinary medicine and science · 2026Article
- Evaluation of Intestinal Barrier Biomarkers and Glucagon-like Peptide-2 in SIRS-Positive and SIRS-Negative Diarrheic Calves.Animals : an open access journal from MDPI · 2026Article
- Identification of gut microbiota features of diarrheic calves using the full-length 16S rRNA gene amplicon sequencing and machine learning.Animal microbiome · 2026Article
- Characterizing bacteremia in neonatal calves with diarrhea: a case-control study.Journal of veterinary internal medicine · 2026Article
- Effects of sweet chestnut (Frontiers in veterinary science · 2026Article
- Effect of storage time on the stability of selected blood gases, electrolytes, and metabolite concentrations in dairy cattle whole blood and plasma.JDS communications · 2026Article
- Optimization of Antimicrobial Use for Sepsis in Calves: Bayesian Evaluation of Existing and Novel Sepsis Scores.Animals : an open access journal from MDPI · 2025Article
- Determining lactate concentrations in Korean indigenous calves and evaluating its role as a predictor for acidemia in calf diarrhea.BMC veterinary research · 2024Article
- Chloride and lactate as prognostic indicators of calf diarrhea from eighty-nine cases.Journal of veterinary science · 2024Article
- Retrospective evaluation of acid-base imbalances, clinicopathologic alterations, and prognostic factors in hospitalized calves with Eimeria-associated diarrhea.Frontiers in veterinary science · 2024Article
- Salivary pH, but not conductivity, is an indicator of diarrhea in neonatal calves.Frontiers in veterinary science · 2024Article
- Association of the type of metabolic acidosis and non-survival of horses with colitis.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Acid-base imbalances and the association of blood-gas variables, electrolytes, and biochemical analytes with outcome in hospitalized calves undergoing abdominal surgery.Journal of veterinary internal medicine · 2023Article
- Role of maternal variables on the development of neonatal hypoglycaemia and influence of neonatal hypoglycaemia on performance of goat kids.Veterinary and animal science · 2023Article
- Surveilling brain damage using brain biomarkers in hypoglycemic neonatal calves with diarrhea.Frontiers in veterinary science · 2023Article
- Sepsis and survival in critically ill calves: Risk factors and antimicrobial use.Journal of veterinary internal medicine · 2023Article
- Evaluation of a point-of-care meter for measuring glucose concentrations in dairy calves: A diagnostic accuracy study.JDS communications · 2022Article
- Serum haptoglobin concentration and liver enzyme activity as indicators of systemic inflammatory response syndrome and survival of sick calves.Journal of veterinary internal medicine · 2022Article
- Associations between Feeding Behaviors Collected from an Automated Milk Feeder and Neonatal Calf Diarrhea in Group Housed Dairy Calves: A Case-Control Study.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Profound acidemia impairs cellular and organ function and consequently should be associated with an increased risk of mortality in critically ill humans and animals. Neonatal diarrhea in calves can result in potentially serious metabolic derangements including profound acidemia due to strong ion (metabolic) acidosis, hyper-D-lactatemia, hyper-L-lactatemia, azotemia, hypoglycemia, hyperkalemia and hyponatremia. The aim of this retrospective study was to assess the prognostic relevance of clinical and laboratory findings in 1,400 critically ill neonatal calves with diarrhea admitted to a veterinary teaching hospital. The mortality rate was 22%. Classification tree analysis indicated that mortality was associated with clinical signs of neurologic disease, abdominal emergencies, cachexia, orthopedic problems such as septic arthritis, and profound acidemia (jugular venous blood pH < 6.85). When exclusively considering laboratory parameters, classification tree analysis identified plasma glucose concentrations < 3.2 mmol/L, plasma sodium concentrations ≥ 151 mmol/L, serum GGT activity < 31 U/L and a thrombocyte count < 535 G/L as predictors of mortality. However, multivariable logistic regression models based on these laboratory parameters did not have a sufficiently high enough sensitivity (59%) and specificity (79%) to reliably predict treatment outcome. The sensitivity and specificity of jugular venous blood pH < 6.85 were 11% and 97%, respectively, for predicting non-survival in this study population. We conclude that laboratory values (except jugular venous blood pH < 6.85) are of limited value for predicting outcome in critically ill neonatal calves with diarrhea. In contrast, the presence of specific clinical abnormalities provides valuable prognostic information.
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