ArticlePloS one2017
The extremely divergent maternally- and paternally-transmitted mitochondrial genomes are co-expressed in somatic tissues of two freshwater mussel species with doubly uniparental inheritance of mtDNA.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 37 citations in OpenAlex.
- Unstable mitochondrial heteroplasmy inPeerJ · 2026Article
- Sex-Specific ORFs in Marine Clams (Bivalvia: Veneridae) with Doubly Uniparental Inheritance: Exploring Their Origin and Putative Function.Marine biotechnology (New York, N.Y.) · 2025Article
- Small-scale habitat heterogeneity and genotype modulate in situ gene expression of the Antarctic bivalve Aequiyoldia eightsii in front of a melting glacier.BMC ecology and evolution · 2025Article
- Demystifying the functions of the mitochondrial ORFan proteins in bivalves with doubly uniparental inheritance.Biology letters · 2025Article
- Mitonuclear compatibility is maintained despite relaxed selection on male mitochondrial DNA in bivalves with doubly uniparental inheritance.Evolution; international journal of organic evolution · 2024Article
- The absence of canonical respiratory complex I subunits in male-type mitogenomes of three Donax species.Scientific reports · 2024Article
- Mitonuclear Sex Determination? Empirical Evidence from Bivalves.Molecular biology and evolution · 2023Article
- A tale of two paths: The evolution of mitochondrial recombination in bivalves with doubly uniparental inheritance.The Journal of heredity · 2023Article
- The longest mitochondrial protein in metazoans is encoded by the male-transmitted mitogenome of the bivalveBiology letters · 2022Article
- Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes.Zoological research · 2022Article
- Bioenergetic consequences of sex-specific mitochondrial DNA evolution.Proceedings. Biological sciences · 2021Article
- Boundaries and hybridization in a secondary contact zone between freshwater mussel species (Family:Unionidae).Heredity · 2021Article
- Molluscan mitochondrial genomes break the rules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA.Genome biology and evolution · 2021Article
- Unorthodox features in two venerid bivalves with doubly uniparental inheritance of mitochondria.Scientific reports · 2020Article
- Variability of mitochondrial ORFans hints at possible differences in the system of doubly uniparental inheritance of mitochondria among families of freshwater mussels (Bivalvia: Unionida).BMC evolutionary biology · 2019Article
- Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria.Proceedings. Biological sciences · 2019Article
- Putative Mitochondrial Sex Determination in the Bivalvia: Insights From a Hybrid Transcriptome Assembly in Freshwater Mussels.Frontiers in genetics · 2019Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freshwater mussel species with doubly uniparental inheritance (DUI) of mtDNA are unique because they are naturally heteroplasmic for two extremely divergent mtDNAs with ~50% amino acid differences for protein-coding genes. The paternally-transmitted mtDNA (or M mtDNA) clearly functions in sperm in these species, but it is still unknown whether it is transcribed when present in male or female soma. In the present study, we used PCR and RT-PCR to detect the presence and expression of the M mtDNA in male and female somatic and gonadal tissues of the freshwater mussel species Venustaconcha ellipsiformis and Utterbackia peninsularis (Unionidae). This is the first study demonstrating that the M mtDNA is transcribed not only in male gonads, but also in male and female soma in freshwater mussels with DUI. Because of the potentially deleterious nature of heteroplasmy, we suggest the existence of different mechanisms in DUI species to deal with this possibly harmful situation, such as silencing mechanisms for the M mtDNA at the transcriptional, post-transcriptional and/or post-translational levels. These hypotheses will necessitate additional studies in distantly-related DUI species that could possess different mechanisms of action to deal with heteroplasmy.
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