ReviewPLoS neglected tropical diseases2017
Caprine brucellosis: A historically neglected disease with significant impact on public health.
Review in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Prevalence, Associated Factors, and Temporal Trends of Brucella Detection Across Human and Animal Hosts in Bangladesh: A 25-Year Meta-Analysis.Veterinary medicine and science · 2026Pooled it
- Beyond Serology: A Meta-Analysis of Advancements in Molecular Detection of Brucella spp. in Seronegative Animals and Biological Samples.Veterinary medicine and science · 2025Pooled it
- A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis.PLoS neglected tropical diseases · 2019Pooled it
- Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis.BMC veterinary research · 2018Pooled it
- Medication adherence and its determinants among Brucellosis patients in China: A multi-center follow-up study.PLoS neglected tropical diseases · 2026Article
- Ability ofMicroorganisms · 2026Article
- Comparison of Various Rose Bengal Plate Tests, Serum Tube Agglutination Tests, and Enzyme-Linked Immunosorbent Assays Used in Brucellosis Serosurveillance in Sheep, Bovines, and Spotted Deer.Veterinary sciences · 2026Article
- Modern Strategies for Brucellosis Vaccination: From Traditional Approaches to Innovative Platforms.Vaccines · 2026Review
- Evaluation of AI-enhanced FTIR spectroscopy for species and biovar typing of intracellular pathogenic Brucella spp.BMC microbiology · 2026Article
- Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.The Journal of biological chemistry · 2026Article
- Endovascular aneurysm repair combined with local and systemic antibacterial treatment for infected aorto-iliac artery aneurysms caused by Brucella.BMC infectious diseases · 2026Article
- Comparison of serological tools for reliable diagnosis of brucellosis circulation in the West-African context.BMC veterinary research · 2026Article
- Article
- Extracellular vesicle microRNA signature as a highly accurate diagnostic biomarker for human brucellosis.Frontiers in cellular and infection microbiology · 2026Article
- Stratum-specific serum metabolic reprogramming in Saanen goats with graded Brucella serological reactivity under natural exposure.Frontiers in veterinary science · 2026Article
- Geographic distribution and genetic diversity of Brucella melitensis from Yunnan province, China.BMC microbiology · 2025Article
- Exploring the status of brucellosis in pregnant women presented with febrile illness at different healthcare facilities of Vehari and Lodhran zones of Pakistan.PLoS neglected tropical diseases · 2025Article
- Brucella orchitis: A case report on a rare cause of scrotal abscess leading to orchiectomy.Urology case reports · 2025Article
- Article
- The Role of Vulture (Accipitriformes) Cutaneous Microbiota in Infectious Disease Protection.Microorganisms · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic clinical signs of the disease that is associated with an extensive negative impact in a flock's productivity. B. melitensis is also the most virulent Brucella species for humans, responsible for a severely debilitating and disabling illness that results in high morbidity with intermittent fever, chills, sweats, weakness, myalgia, abortion, osteoarticular complications, endocarditis, depression, anorexia, and low mortality. Historical observations indicate that goats have been the hosts of B. melitensis for centuries; but around 1905, the Greek physician Themistokles Zammit was able to build the epidemiological link between "Malta fever" and the consumption of goat milk. While the disease has been successfully managed in most industrialized countries, it remains a significant burden on goat and human health in the Mediterranean region, the Middle East, Central and Southeast Asia (including India and China), sub-Saharan Africa, and certain areas in Latin America, where approximately 3.5 billion people live at risk. In this review, we describe a historical evolution of the disease, highlight the current worldwide distribution, and estimate (by simple formula) the approximate costs of brucellosis outbreaks to meat- and milk-producing farms and the economic losses associated with the disease in humans. Successful control leading to eradication of caprine brucellosis in the developing world will require a coordinated Global One Health approach involving active involvement of human and animal health efforts to enhance public health and improve livestock productivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.