ArticlePloS one2017
Genetic diversity of the O antigens of Proteus species and the development of a suspension array for molecular serotyping.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Genomic Insights of Emerging Multidrug-Resistant OXA-48-Producing ST135Antibiotics (Basel, Switzerland) · 2025Article
- Unveiling Genomic Islands Hosting Antibiotic Resistance Genes and Virulence Genes in Foodborne Multidrug-Resistant Patho-GenicBiology · 2025Article
- Recent insights into Wzy polymerases and lipopolysaccharide O-antigen biosynthesis.Journal of bacteriology · 2025Review
- Genomic insights into a Proteus mirabilis strain inducing avian cellulitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Identification and Functional Analysis of ncRNAs Regulating Intrinsic Polymyxin Resistance in FoodborneMicroorganisms · 2024Article
- Structural and Serological Characterization of the O Antigen ofInternational journal of molecular sciences · 2023Article
- Phosphocholine decoration ofCell surface (Amsterdam, Netherlands) · 2022Article
- The Identification of Ethidium Bromide-Degrading Bacteria from Laboratory Gel Electrophoresis Waste.Biotech (Basel (Switzerland)) · 2022Article
- Characterization of Structure and Antioxidant Activity of Polysaccharides From Sesame Seed Hull.Frontiers in nutrition · 2022Article
- The prevailing O serogroups among the serologically differentiated clinical Proteus spp. strains in central Poland.Scientific reports · 2021Article
- Development of a Molecular Serotyping Scheme forFrontiers in microbiology · 2021Article
- Draft Genome ofFrontiers in cellular and infection microbiology · 2021Article
- Multidrug-ResistantMicroorganisms · 2020Article
- Cell Shape and Population Migration Are Distinct Steps ofJournal of bacteriology · 2019Article
- O-Antigen Gene Clusters ofFrontiers in microbiology · 2019Article
- Development of rapid and simple experimental and in silico serotyping systems for Citrobacter.Future microbiology · 2018Article
- Proteus spp. as Putative Gastrointestinal Pathogens.Clinical microbiology reviews · 2018Review
- Professor Krystyna Kotełko and her contribution to the study of Proteus endotoxin.Innate immunity · 2018Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Proteus species are well-known opportunistic pathogens frequently associated with skin wound and urinary tract infections in humans and animals. O antigen diversity is important for bacteria to adapt to different hosts and environments, and has been used to identify serotypes of Proteus isolates. At present, 80 Proteus O-serotypes have been reported. Although the O antigen structures of most Proteus serotypes have been identified, the genetic features of these O antigens have not been well characterized. The O antigen gene clusters of Proteus species are located between the cpxA and secB genes. In this study, we identified 55 O antigen gene clusters of different Proteus serotypes. All clusters contain both the wzx and wzy genes and exhibit a high degree of heterogeneity. Potential functions of O antigen-related genes were proposed based on their similarity to genes in available databases. The O antigen gene clusters and structures were compared, and a number of glycosyltransferases were assigned to glycosidic linkages. In addition, an O serotype-specific suspension array was developed for detecting 31 Proteus serotypes frequently isolated from clinical specimens. To our knowledge, this is the first comprehensive report to describe the genetic features of Proteus O antigens and to develop a molecular technique to identify different Proteus serotypes.
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